Martínez-Salazar María Fernanda, Oaxaca-Navarro Jesús, Leija-Salas Alfonso, García-Jiménez Sara, Sánchez-Alemán Miguel Angel, Déciga-Campos Myrna
Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México.
CAPASITS Cuernavaca, Servicios de Salud del Estado de Morelos, Cuernavaca, Morelos, México.
Eur J Hosp Pharm. 2018 Nov;25(6):322-326. doi: 10.1136/ejhpharm-2016-001106. Epub 2017 Mar 16.
To analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico.
Cross-sectional study conducted in a clinic specialising in HIV 'CAPASITS-Cuernavaca' in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student's t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ test was used. All tests used a significance level of 0.05.
A total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people.
The results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.
分析墨西哥莫雷洛斯州库埃纳瓦卡市一组艾滋病毒感染者中最常见的自我报告的不良反应、抗逆转录病毒药物（ARV）治疗方案改变的持续性和原因、伴随治疗以及与使用ARV相关的药物相互作用。
2015年2月至6月在墨西哥一家专门治疗艾滋病毒的“库埃纳瓦卡CAPASITS”诊所进行横断面研究。愿意参与的人被给予一份关于人口统计学特征、依从性、伴随治疗和不良反应的问卷。为了解临床变量，查阅了临床记录。对于定量变量，使用学生t检验比较正态数据，使用曼-惠特尼U检验比较非正态数据。对于分类变量之间的比较，使用χ检验。所有检验的显著性水平均为0.05。
共有96人参与，共发现218例不良反应（平均=2.3±1.9）。最常遇到的不良反应是头晕（53.1%）、失眠（21.9%）和清醒梦（17.7%）。23人（24%）使用多种药物，在12人身上检测到18种潜在相互作用。
结果表明，对于接受ARV治疗且使用多种药物的患者，应全面分析可能的药物相互作用，并应设计一个不良反应监测和管理方案，以确保良好的ARV治疗依从性。
