Senior Scientist Group Nutrition, Immunity & Metabolism, Department of Nutrition & Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Biomark Med. 2019 Jun;13(8):639-648. doi: 10.2217/bmm-2018-0351. Epub 2019 Jun 3.
Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-β, suPAR and clusterin. Intraclass correlation coefficients (95% CIs) ranged from good for TGF-β (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0.93]). Measurement of TGF-β was challenged by the large number of values below the detection limit. Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.
评估免疫炎症生物标志物测量的可行性和可靠性。在 207 名主要健康参与者的基线和 4 个月后，评估了以下生物标志物：MMF、TGF-β、suPAR 和 clusterin。内类相关系数（95%置信区间）范围从 TGF-β 的良好（0.75 [95% CI：0.33-0.90]）到 MMF 的优秀（0.81 [95% CI：0.64-0.90]）、clusterin（0.83 [95% CI：0.78-0.87]）和 suPAR（0.91 [95% CI：0.88-0.93]）。由于大量值低于检测限，TGF-β 的测量受到了挑战。suPAR、clusterin 和 MMF 的单次测量可以作为生物医学研究中免疫炎症途径的可行和可靠的生物标志物。
