他汀类药物治疗患者的肌肉损伤生化标志物和肌酸激酶血清浓度升高。
Biochemical markers of muscle damage and high serum concentration of creatine kinase in patients on statin therapy.
机构信息
Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil.
出版信息
Biomark Med. 2019 Jun;13(8):619-626. doi: 10.2217/bmm-2018-0379. Epub 2019 Jun 3.
Some patients experience statin-associated muscle symptoms (SAMS) and elevated serum concentrations of CK. The relationship between SAMS and biomarkers of muscle damage was examined. We analyzed 359 consecutive patients taking statins with high CK values. Muscle-related symptoms and biochemical variables, including CK, MB isoenzyme of creatine kinase (CK-MB), troponin and carbonic anhydrase type III were evaluated. SAMS was reported by 181 (50.4%) patients and they had greater BMI (p = 0.021) and a trend toward higher CK-MB values (p = 0.064). The use of simvastatin (OR: 2.24; 95% CI: 1.47-3.42), CK-MB (OR: 1.59; 95% CI: 1.02-2.49) and BMI (OR: 1.06; 95% CI: 1.01-1.10) were independent variables for SAMS. Simvastatin use, BMI and CK-MB were independent markers of SAMS.
一些患者会出现他汀类药物相关肌肉症状（SAMS）和血清肌酸激酶（CK）浓度升高。本研究旨在探究 SAMS 与肌肉损伤生物标志物之间的关系。我们分析了 359 例因 CK 值升高而服用他汀类药物的连续患者。评估了与肌肉相关的症状和生化变量，包括 CK、肌酸激酶同工酶（CK-MB）、肌钙蛋白和碳酸酐酶 III。181 例（50.4%）患者报告出现 SAMS，他们的 BMI 更高（p=0.021），且 CK-MB 值更高（p=0.064）。使用辛伐他汀（OR：2.24；95%CI：1.47-3.42）、CK-MB（OR：1.59；95%CI：1.02-2.49）和 BMI（OR：1.06；95%CI：1.01-1.10）是 SAMS 的独立变量。辛伐他汀的使用、BMI 和 CK-MB 是 SAMS 的独立标志物。
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