感音神经性听力损失患者脑灰质体积和白质完整性的改变：基于体素和基于束的形态测量学研究。
Altered Gray Matter Volume and White Matter Integrity in Sensorineural Hearing Loss Patients: A VBM and TBSS Study.
机构信息
Department of Radiology.
Department of Ear, Nose and Throat, the Second Hospital of Anhui Medical University.
出版信息
Otol Neurotol. 2019 Jul;40(6):e569-e574. doi: 10.1097/MAO.0000000000002273.
OBJECTIVE
The purpose of the present study was to detect structural changes in the brains of patients with sensorineural hearing loss (SNHL) by combining voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS).
METHODS
Thirty-five patients with SNHL (mean age: 39.72 ± 1.81 yr) and 23 age-matched control subjects (mean age: 39.83 ± 1.96 yr) were assessed using three-dimensional, T1-weighted imaging, and diffusion tensor imaging. TBSS and VBM analyses were performed to evaluate grey matter (GM) volume changes and white matter (WM) alternations, as measured by mean diffusivity (MD), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD).
RESULTS
VBM showed decreased GM volume in patients with SNHL in the fusiform gyrus of the right temporal lobe and right middle occipital gyrus. TBSS revealed WM integrity changes, including decreased FA and RD and increased RD in several WM regions. However, MD showed no significant difference between patients with SNHL and age-matched controls.
CONCLUSION
Patients with SNHL showed smaller GM volume and WM integrity changes in several regions.
目的
本研究旨在通过体素形态计量学（VBM）和基于束的空间统计学（TBSS）结合来检测感音神经性听力损失（SNHL）患者大脑的结构变化。
方法
对 35 名 SNHL 患者（平均年龄：39.72±1.81 岁）和 23 名年龄匹配的对照组（平均年龄：39.83±1.96 岁）进行了三维、T1 加权成像和弥散张量成像评估。进行 TBSS 和 VBM 分析以评估 GM 体积变化和 WM 变化，通过平均弥散度（MD）、各向异性分数（FA）、轴向弥散度（AD）和径向弥散度（RD）来衡量。
结果
VBM 显示 SNHL 患者右侧颞叶和右侧中枕叶的梭状回 GM 体积减少。TBSS 显示 WM 完整性变化，包括几个 WM 区域的 FA 和 RD 降低以及 RD 增加。然而，MD 显示 SNHL 患者与年龄匹配的对照组之间没有显著差异。
结论
SNHL 患者在几个区域显示 GM 体积较小和 WM 完整性变化。
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