IncA/C 质粒上的多个 解释了大肠杆菌突变株中增强的喹诺酮类药物耐药性。
Multiple Copies of on an IncA/C Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant.
机构信息
Massachusetts General Hospital, Boston, Massachusetts, USA
Day Zero Diagnostics, Boston, Massachusetts, USA.
出版信息
Antimicrob Agents Chemother. 2019 Jul 25;63(8). doi: 10.1128/AAC.00718-19. Print 2019 Aug.
Abstract
In a previous study, mutants with enhanced ciprofloxacin resistance (Cip) were selected from J53/pMG252 carrying Strain J53 Cip 8-2 showed an increase in the copy number and transcription level of We sequenced the plasmids on Illumina and MinION platforms. Parental plasmid pMG252 and plasmid pMG252A from strain J53 Cip 8-2 were almost identical, except for the region containing that in pMG252A contained 4 additional copies of the Δ-IS region.
摘要
在之前的一项研究中，从携带 J53/Cip8-2 的 J53/pMG252 中选择了对环丙沙星耐药性增强的突变体 J53/Cip8-2 中质粒 pMG252A 与来自 J53/Cip8-2 的质粒 pMG252 几乎相同，除了含有 序列的区域。在 pMG252A 中，该区域包含 Δ-IS 区的 4 个额外拷贝。
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