Roa Jorge A, Guevara Alexandra, Guevara Carolina, Guevara-Aguirre Jaime
Department of Diabetes and Endocrinology, College of Medicine, Universidad San Francisco de Quito, Quito, Pichincha, Ecuador.
Instituto de Endocrinologia y Metabolismo, IEMYR, Quito, Pichincha, Ecuador.
BMJ Case Rep. 2019 Jun 2;12(6):e227072. doi: 10.1136/bcr-2018-227072.
In developed countries, addressing the growing opioid addiction epidemic is focused on preventive measures, developing better overdose-reversal medications and designing newer strategies to treat addiction. Primary prescribers of the therapeutic use of opioids might play a definite role in the aetiology of the epidemics. Developing countries could be affected by similar issues; however, given that no updated statistics are available, it is possible that their populations undergo problems similar to those for which current data is available. Concerns have arisen regarding synthetic opioid tramadol which, given its fast and potent analgesic effects, low cost and easy availability is widely prescribed. A debate remains as to whether tramadol induces addictive effects like those of stronger analogues such as oxycodone or fentanyl. Here we present a case of tramadol dependence in an Ecuadorian patient and find that substance abuse can occur in normal individuals affected by chronic pain, otherwise treatable with standard methods.
在发达国家,应对日益严重的阿片类药物成瘾流行问题主要集中在预防措施、研发更好的过量用药逆转药物以及设计新的成瘾治疗策略上。阿片类药物治疗用途的主要开方者可能在该流行病因中起一定作用。发展中国家可能也会受到类似问题的影响;然而,鉴于目前尚无最新统计数据,其人口可能面临与现有数据所反映问题类似的情况。人们对合成阿片类药物曲马多产生了担忧,因其具有快速强效的镇痛作用、低成本且易于获取,因而被广泛开方使用。关于曲马多是否会像羟考酮或芬太尼等更强效类似物那样产生成瘾作用,仍存在争议。在此,我们报告一例厄瓜多尔患者曲马多依赖的病例,并发现慢性疼痛患者(原本可通过标准方法治疗)即使是正常人也可能出现药物滥用情况。