人类和动物研究中神经肌肉接头老化研究结果概述
An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies.
作者信息
Khosa Shaweta, Trikamji Bhavesh, Khosa Gurveer S, Khanli Hadi M, Mishra Shri K
机构信息
Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States.
Department of Neurology, Harbor UCLA Medical Center, Torrance, CA 90502, United States.
出版信息
Curr Aging Sci. 2019;12(1):28-34. doi: 10.2174/1874609812666190603165746.
BACKGROUND
Aging is a complex irreversible process that is not only related to an individual's genetic make-up but also to lifestyle choices and environmental exposures. Like every other structure in human body, the Neuromuscular Junction (NMJ) is not averse to aging.
OBJECTIVES
The prime objective is to analyse the microscopic and macroscopic changes at the NMJs with aging.
METHODS
For the purpose of review we evaluated data from resources like Pubmed, Ovid, UCLA libraries and USC libraries.
RESULTS
We review various morphological, physiological, immunological, and biochemical changes in NMJs with aging and their management.
CONCLUSION
The alterations in NMJs secondary to aging are inevitable. It is vital that neurologists clearly understand the pathophysiology of NMJ aging and differentiate between physiological and pathological effects of aging. With the current knowledge of science, the changes in NMJ aging can be better prevented rather than cured.
背景
衰老过程复杂且不可逆，不仅与个体的基因组成有关，还与生活方式的选择和环境暴露相关。与人体的其他结构一样，神经肌肉接头（NMJ）也会受到衰老的影响。
目的
主要目的是分析神经肌肉接头随衰老发生的微观和宏观变化。
方法
为进行综述，我们评估了来自PubMed、Ovid、加州大学洛杉矶分校图书馆和南加州大学图书馆等资源的数据。
结果
我们综述了神经肌肉接头随衰老发生的各种形态学、生理学、免疫学和生化变化及其处理方法。
结论
衰老继发的神经肌肉接头改变是不可避免的。神经科医生清楚了解神经肌肉接头衰老的病理生理学，并区分衰老的生理和病理效应至关重要。基于目前的科学知识，神经肌肉接头衰老的变化能够得到更好的预防而非治愈。
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