Lu Yinian, Yong Jun, Xia Yin, Liu Zhilian
Department of Otolaryngology Head and Neck Surgery，the First Affiliated Hospital of Xinjiang Medical University，Urumqi，830000，China.
Department of Otolaryngology Head and Neck Surgery，Beijing Tiantan Hospital，Capital Medical University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Nov;36(11):827-834. doi: 10.13201/j.issn.2096-7993.2022.11.004.
To investigate the relationship between the severity and curative effect of hearing loss and clinical indicators in patients with sudden hearing loss （SHL）. The Spearman correlation coefficient was used to analyze the correlation between the efficacy of SHL and clinical indicators.A total of two hundred and seventy-three patients with SHL were selected and divided into three quantile groups according to the average hearing threshold of the the involved ear frequency of the first pure tone audiometry at admission. Univariate and multivariate ordered logistic regression were used to evaluate the relationship between initial hearing level and clinical indicators of SHL patients. The Spearman correlation coefficient was used to analyze the correlation between efficacy of SHL and clinical indicators. Compared with patients with lower hearing loss （≤50 dB HL），patients with higher hearing loss （>50 dB HL） had higher Neutrophil, Monocyte, Triglycerides, Hemoglobin, Fibrinogen, Glucose, Neutrophil/high-density lipoprotein cholesterol ratio （NHR）, Monocyte/high-density lipoprotein cholesterol ratio, Monocyte/lymphocyte cell ratio, age, dizziness, and lower Platelet/ lymphocyte cell ratio and High-density lipoprotein cholesterol, and poor final hearing threshold.Multivariate logistic regression showed that NHR and age were independent risk factors for initial hearing loss in SHL patients.And the NHR, Neutrophil/lymphocyte cell ratio （NLR）, course of disease, type of hearing curve, and final hearing threshold were significantly negatively correlated with curative effect. SHL patients with higher NHR and NLR values, the longer time from onset to visit, and the more severe hearing loss had worse efficacy.However, SHL patients with higher NHR and age values had greater initial hearing loss,the degree of hearing loss and curative effect are different in SHL patients with different types of hearing threshold curve and age.
探讨突发性聋（SHL）患者听力损失严重程度与疗效及临床指标之间的关系。采用Spearman相关系数分析SHL疗效与临床指标的相关性。选取273例SHL患者，根据入院时首次纯音听力测定患耳频率平均听阈分为三个分位数组。采用单因素和多因素有序logistic回归评估SHL患者初始听力水平与临床指标的关系。采用Spearman相关系数分析SHL疗效与临床指标的相关性。与听力损失较低（≤50 dB HL）的患者相比，听力损失较高（>50 dB HL）的患者中性粒细胞、单核细胞、甘油三酯、血红蛋白、纤维蛋白原、葡萄糖、中性粒细胞/高密度脂蛋白胆固醇比值（NHR）、单核细胞/高密度脂蛋白胆固醇比值、单核细胞/淋巴细胞比值、年龄、头晕较高，血小板/淋巴细胞比值和高密度脂蛋白胆固醇较低，最终听阈较差。多因素logistic回归显示，NHR和年龄是SHL患者初始听力损失的独立危险因素。且NHR、中性粒细胞/淋巴细胞比值（NLR）、病程、听力曲线类型及最终听阈与疗效呈显著负相关。NHR和NLR值较高、起病至就诊时间较长、听力损失较严重的SHL患者疗效较差。然而，NHR和年龄值较高的SHL患者初始听力损失较大，不同听阈曲线类型和年龄的SHL患者听力损失程度及疗效不同。
