[Functional status of beta-cells of the pancreas in long-term administration of hypoglycemic sulfanilamides in patients with glucose tolerance disorder].

The levels of immunoreactive insulin and C-peptide were determined against a background of the GTT and GTT + prednisolone in patients with glucose intolerance before and 3-6 mos. after sulfanilamide therapy to study the effect of a prolonged use of glibenclamide (manilil) on compensatory-reserve function of beta-cells. The hypoglycemic effect of these drugs was determined by their extrahepatic action. The normalization of the body sensitivity to insulin was established. A prolonged use of sugar lowering sulfanilamides did not make a depleting effect on beta-cell function. The results obtained were in favor of the administration of glibenclamide to patients with disturbed glucose tolerance.