Srikanta S, Ganda O P, Gleason R E, Jackson R A, Soeldner J S, Eisenbarth G S
Diabetes. 1984 Aug;33(8):717-20. doi: 10.2337/diab.33.8.717.
Twenty-one intravenous (i.v.) glucose tolerance tests were performed on nine subjects before the onset of overt type I diabetes mellitus. Islet cell antibodies (6 of 9 subjects) and elevated levels of Ia-positive T-lymphocytes (3 of 3 subjects studied) were detected during the prediabetic period. Elevations of fasting blood glucose and peak glucose during oral glucose tolerance tests were not observed until the year before onset of clinically overt diabetes. During the prediabetic period, there was a progressive loss of early-phase insulin release to i.v. glucose (rate of decline, 20-40 microU/ml insulin release/yr; correlation coefficient, 0.9).
在9名1型糖尿病显性发作前的受试者身上进行了21次静脉注射葡萄糖耐量试验。在糖尿病前期检测到胰岛细胞抗体（9名受试者中的6名）和Ia阳性T淋巴细胞水平升高（所研究的3名受试者中的3名）。直到临床显性糖尿病发作前一年，口服葡萄糖耐量试验期间空腹血糖和血糖峰值才出现升高。在糖尿病前期，静脉注射葡萄糖后早期胰岛素释放逐渐丧失（下降速率为20 - 40微单位/毫升胰岛素释放/年；相关系数为0.9）。
