两个分子的烯丙基酮与异腈的双环化反应：含内酯氮杂螺环衍生物的合成
A bicyclization reaction with two molecular allenyl ketones and isocyanides: synthesis of a lactone-containing azaspirocycle derivative.
作者信息
Yuan Hongdong, Tang Chongrong, Su Shikuan, Cui Lei, Jia Xueshun, Li Chunju, Li Jian
机构信息
Department of Chemistry, Center for Supramolecular Chemistry and Catalysis, College of Sciences & Institute of Sustainable Energy, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China.
Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry, Ministry of Education, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China.
出版信息
Chem Commun (Camb). 2019 Jun 25;55(50):7231-7234. doi: 10.1039/c9cc02785h. Epub 2019 Jun 5.
A novel bicyclization reaction of two molecular allenyl ketones and isocyanides has been disclosed. This strategy allows for the construction of structurally complex spirocyclic lactam-lactone systems in an efficient manner. This protocol also demonstrates other advantages such as high synthetic efficiency, atom economy, and broad substrate scope under mild conditions.
已公开了一种新型的两个分子烯丙基酮与异腈的双环化反应。该策略能够以高效的方式构建结构复杂的螺环内酰胺 - 内酯体系。该方法还展现出其他优势，如合成效率高、原子经济性好以及在温和条件下底物范围广。
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