Yerushalmi A, Weinstein Y
Cancer Res. 1979 Mar;39(3):1126-8.
Host resistance to tumor growth was studied in athymic nude mice of C57BL background. Animals were pretreated in the left hind leg by local hyperthermia, local X-irradiation, or combined local hyperthermia and X-irradiation. Twenty-four hr posttreatment, the animals were inoculated with the metastatic Lewis lung carcinoma tumor. Half of the animals in each group were inoculated in the pretreated leg and animals of the other half of the group were inoculated in the contralateral untreated leg. An increase of 30 to 45% in life span was achieved in normal and nude mice pretreated by combined local hyperthermia and irradiation. The increase in life span was similar in animals inoculated in the pretreated leg or in the untreated contralateral leg. These results indicate that T-lymphocytes are not involved in the protection against tumor growth.
在C57BL背景的无胸腺裸鼠中研究了宿主对肿瘤生长的抵抗力。动物的左后肢预先接受局部热疗、局部X射线照射或局部热疗与X射线照射联合治疗。治疗后24小时，给动物接种转移性Lewis肺癌肿瘤。每组一半的动物在预先处理过的腿上接种，另一半动物在对侧未处理的腿上接种。联合局部热疗和照射预处理的正常小鼠和裸鼠的寿命延长了30%至45%。在预先处理过的腿上接种或在未处理的对侧腿上接种的动物，其寿命延长情况相似。这些结果表明，T淋巴细胞不参与对肿瘤生长的保护作用。
