Halila H, Huhtala M L, Haglund C, Nordling S, Stenman U H
First Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.
Br J Cancer. 1987 Aug;56(2):153-6. doi: 10.1038/bjc.1987.175.
The levels of tumour-associated trypsin inhibitor (TATI), CA 125 and CEA were measured in ovarian cyst fluids from 21 patients. TATI in cyst fluid was immunologically and physicochemically similar to the peptide originally isolated from the urine of a patient with ovarian cancer. Mucinous cysts contained significantly higher levels of TATI than did serous cysts. Immunohistochemically TATI was localized in the apical parts of cells of mucinous ovarian cysts. These results suggest that this tumour-associated peptide is actually produced by a tumour. Like TATI, CEA occurred at higher concentrations in mucinous than in serous cyst fluids, whereas CA 125 was found in higher concentrations in serous than in mucinous cyst fluids. The concentrations of these tumours markers in cyst fluids did not correlate with circulating levels of the same markers. In spite of the very high levels of all these tumour markers in benign cyst fluids, serum levels were normal or only slightly elevated. Clearly elevated serum levels occurred only in patients with malignant tumours. Cyst fluid levels of these tumour markers could not be used to distinguish between benign and malignant tumours.
检测了21例患者卵巢囊肿液中肿瘤相关胰蛋白酶抑制剂（TATI）、CA 125和癌胚抗原（CEA）的水平。囊肿液中的TATI在免疫和物理化学性质上与最初从一名卵巢癌患者尿液中分离出的肽相似。黏液性囊肿中TATI的水平显著高于浆液性囊肿。免疫组织化学显示TATI定位于卵巢黏液性囊肿细胞的顶端部分。这些结果表明这种肿瘤相关肽实际上是由肿瘤产生的。与TATI一样，CEA在黏液性囊肿液中的浓度高于浆液性囊肿液，而CA 125在浆液性囊肿液中的浓度高于黏液性囊肿液。囊肿液中这些肿瘤标志物的浓度与相同标志物的循环水平无关。尽管在良性囊肿液中所有这些肿瘤标志物的水平都非常高，但血清水平正常或仅略有升高。血清水平明显升高仅发生在恶性肿瘤患者中。这些肿瘤标志物的囊肿液水平不能用于区分良性和恶性肿瘤。
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