Department of Ophthalmology.
Department of Radiology, The First Hospital of Jilin University, No. 71 of xinmin St., Changchun, Jilin Province, 130021, China.
Int J Med Sci. 2019 Mar 10;16(4):513-518. doi: 10.7150/ijms.29750. eCollection 2019.
Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs produced by back-splicing. They are found to be expressed in eukaryotic cells and play certain roles in various cellular functions, including fibrosis, cell proliferation, differentiation, apoptosis and angiogenesis. Dysregulated circRNAs are found in several human disorders including, malignancy, vascular, inflammatory as well as nervous diseases. Although, increasing evidence suggests that circRNAs may also contribute in different ocular diseases, the outline of circRNAs in ocular diseases remains obscure. In this review we consider the current state of knowledge regarding the potential role and underlying mechanism of circRNAs in ocular diseases including pterygium, age-related cataract, glaucoma, diabetic retinopathy, retinoblastoma, retinal vascular dysfunction and hyperhomocysteinemia induced ocular diseases, emphasizing that circRNAs could be promising biomarkers for the diagnosis and prognosis evaluation. Future circRNAs-targeted intervention may become a novel therapeutic tool for the treatment of ocular diseases.
环状 RNA（circRNAs）是一类新型的内源性非编码 RNA，通过反向剪接产生。它们在真核细胞中表达，并在多种细胞功能中发挥一定作用，包括纤维化、细胞增殖、分化、凋亡和血管生成。在几种人类疾病中发现了失调的 circRNAs，包括恶性肿瘤、血管、炎症和神经疾病。尽管越来越多的证据表明 circRNAs 也可能参与不同的眼部疾病，但 circRNAs 在眼部疾病中的作用机制仍不清楚。在这篇综述中，我们考虑了目前关于 circRNAs 在眼部疾病中的潜在作用及其潜在机制的知识状态，包括翼状胬肉、年龄相关性白内障、青光眼、糖尿病视网膜病变、视网膜母细胞瘤、视网膜血管功能障碍和高同型半胱氨酸血症引起的眼部疾病，强调 circRNAs 可能是诊断和预后评估有前途的生物标志物。未来针对 circRNAs 的干预可能成为治疗眼部疾病的一种新的治疗工具。
