a Department of Orthopedics, South Hospital of Shanghai Sixth People's Hospital/Shanghai Fengxian District Central Hospital, Shanghai , China.
b Department of Orthopedics, Shanghai Sixth People's Hospital , Shanghai , China.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2298-2305. doi: 10.1080/21691401.2019.1622554.
Photothermal therapy (PTT) is a rapidly developing approach for cancer therapy, which has been widely recognized to exert high efficacy as compared to chemotherapy. However, the limited tumour homing property of currently available drug delivery systems (DDSs) is the bottleneck for the efficient delivery of photothermal agents. Here in this study, we surface modified silica nanoparticles (SLN) with the cell membrane (CM) derived from 143B cells to construct a platform (CM/SLN) capable of targeting the homogenous 143B cells. In addition, indocyanine green (ICG) as a photothermal agent was encapsulated into CM/SLN to finally construct a DDS suitable for tumour-targeted PTT of osteosarcoma. Our results revealed that CM/SLN/ICG was mono-dispersed core-shell nanoparticles with advanced stability in a physiological environment. Moreover, due to the modification of CM, CM/SLN/ICG could specifically target the homogenous 143B cells both and , which demonstrated superior anticancer efficacy when compared with either SLN/ICG or free ICG. Hence, CM/SLN/ICG could be a promising DDS for tumour targeted PTT of osteosarcoma.
光热疗法（PTT）是一种治疗癌症的快速发展的方法，与化疗相比，其疗效已被广泛认可。然而，目前可用的药物输送系统（DDS）的肿瘤归巢特性有限，是光热剂有效输送的瓶颈。在本研究中，我们用来源于 143B 细胞的细胞膜（CM）对硅纳米颗粒（SLN）进行表面修饰，构建了一个能够靶向同源 143B 细胞的平台（CM/SLN）。此外，将吲哚菁绿（ICG）作为光热剂包封到 CM/SLN 中，最终构建了一种适用于骨肉瘤肿瘤靶向 PTT 的 DDS。我们的结果表明，CM/SLN/ICG 是单分散的核壳纳米颗粒，在生理环境中具有较高的稳定性。此外，由于 CM 的修饰，CM/SLN/ICG 可以特异性地靶向同质的 143B 细胞，无论是在 还是 ，与 SLN/ICG 或游离 ICG 相比，都表现出优异的抗癌效果。因此，CM/SLN/ICG 可能是一种有前途的骨肉瘤肿瘤靶向 PTT 的 DDS。
