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性别和种族/族裔对住院冠状动脉旁路移植术死亡率趋势的影响——1998-2015 年:为什么差异仍然存在?

Trends in In-hospital Coronary Artery Bypass Surgery Mortality by Gender and Race/Ethnicity --1998-2015: Why Do the Differences Remain?

机构信息

Emory School of Public Health, Atlanta, GA, USA.

Emory University, Atlanta, GA, USA.

出版信息

J Natl Med Assoc. 2019 Oct;111(5):527-539. doi: 10.1016/j.jnma.2019.04.009. Epub 2019 Jun 4.

Abstract

BACKGROUND AND AIMS

Between 1998 and 2015, the national coronary artery bypass graft surgery (CABG) in-hospital mortality rate fell nearly 45% to just 2.2% of CABG in-patients. By almost any standards, this large decline in the nation's in-hospital mortality for CABG inpatients has been extraordinary. Yet, over this time period, no studies have detailed these notable trends in in-hospital CABG mortality with an emphasis on the differences by gender and racial/ethnicity. The in-hospital CABG treatment period is the approximately 9 day inpatient length-of-stay the patient is completely under the care of hospital and its staff. Our research seeks to fill this research gap with analyses of 18 years of national data of over 5 million CABG inpatient discharges distinguishing gender by six categories of race/ethnicity (Asian, black, Hispanic, white, other known races/ethnicities, and unknown race/ethnicities) to evaluate three broad questions related to in-hospital CABG mortality: 1) What have been the 18-year national trends in CABG surgeries, length-of-stay, mortality, and type of discharge by gender and race/ethnicity? 2) Over time, what have been the in-hospital mortality trends by gender and race-ethnicity? 3) Using multivariate techniques to control for patient characteristics, risk factors and socioeconomic characteristics of the hospital setting and environment, what is the extent of the variations in in-hospital mortality among the 12 groupings of gender and race-ethnicity?

DATA AND METHODS

Data are from the Nationwide Inpatient Sample (NIS) data from the Healthcare Utilization Project (HCUP-NIS) collected yearly. These data represent 858 hospitals, a 20% national sample representing 5,032,985 CABG patient discharges from hospitals over an 18-year period -- 1998 to 2015. Descriptive and logistic regression analyses are used to evaluate the outcomes.

RESULTS

The national decline in in-hospital CABG mortality trends over the 18-year period has been dramatic. These declines have substantially impacted all 12 racial/ethnic and gender groupings analyzed during this timeframe. However, over the 18-year period, both univariate and logistic regression results reveal the disadvantages females and black males have in in-hospital CABG mortality rates when compared to the comparison group, white male CABG inpatients. Female CABG inpatients consistently, regardless of their race/ethnicity, have significantly higher in-hospital mortality rates than their corresponding male counterparts even after controlling for patient characteristics and socio-economic status. For males, however, the likelihood of dying in the hospital from a CABG procedure showed wide variation across the four racial/ethnic categories. Compared with white male patients undergoing CABG surgery in the nation's hospitals, after controlling for confounding factors, Hispanic and Asian-American had significantly lower in-hospital CABG mortality rates -9.7% and -17.9% respectively. In contrast, black male CABG patients had a 35.1% higher in-hospital CABG mortality rate than white males.

CONCLUSIONS

While considerable progress has been made reducing overall in-hospital CABG mortality over the past 18-years across all gender and racial/ethnic inpatients, significant gaps persist between black males and other racial/ethnic groups.

摘要

背景和目的

1998 年至 2015 年间,全国冠状动脉旁路移植术(CABG)住院死亡率下降了近 45%,降至 CABG 住院患者的 2.2%。按照几乎任何标准衡量,全国 CABG 住院患者的住院死亡率大幅下降都是非常显著的。然而,在此期间,没有研究详细描述 CABG 住院死亡率的这些显著趋势,也没有强调性别和种族/民族的差异。CABG 的住院治疗期是指患者完全由医院及其工作人员护理的大约 9 天的住院时间。我们的研究旨在通过分析 18 年的全国超过 500 万例 CABG 住院患者的数据来填补这一研究空白,该数据根据六种种族/民族类别(亚裔、黑人、西班牙裔、白人、其他已知种族/民族和未知种族/民族)区分了性别,以评估与 CABG 住院死亡率相关的三个广泛问题:1)CABG 手术、住院时间、死亡率和出院类型在 18 年内按性别和种族/民族的全国趋势如何?2)随着时间的推移,性别和种族/民族的住院死亡率趋势如何?3)使用多元技术来控制患者特征、风险因素和医院环境的社会经济特征,在 12 个性别和种族/民族分组中,住院死亡率的变化程度如何?

数据和方法

数据来自医疗保健利用项目(HCUP-NIS)的全国住院患者样本(NIS)数据,该数据每年收集一次。这些数据代表了来自 858 家医院的 5032985 名 CABG 患者出院的数据,代表了 1998 年至 2015 年期间全国 20%的样本。使用描述性和逻辑回归分析来评估结果。

结果

在 18 年期间,全国 CABG 住院死亡率趋势的下降是巨大的。这些下降对本研究时间段内分析的所有 12 个种族/民族和性别群体都产生了重大影响。然而,在 18 年期间,无论是单变量还是逻辑回归结果都表明,与比较组(白人男性 CABG 住院患者)相比,女性和黑人男性在 CABG 住院死亡率方面存在劣势。女性 CABG 住院患者无论其种族/民族如何,其住院死亡率都明显高于相应的男性患者,即使在控制了患者特征和社会经济地位后也是如此。然而,对于男性来说,从 CABG 手术中死亡的可能性在四个种族/民族类别中存在很大差异。与在全国医院接受 CABG 手术的白人男性患者相比,在控制混杂因素后,西班牙裔和亚裔美国人的 CABG 住院死亡率显著降低,分别为 9.7%和 17.9%。相比之下,黑人男性 CABG 患者的 CABG 住院死亡率比白人男性高 35.1%。

结论

尽管在过去 18 年中,所有性别和种族/民族的 CABG 住院患者的总体住院死亡率都有了相当大的下降,但黑人和其他种族/民族群体之间仍然存在显著差距。

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