Barkai Or, Assalia Ahmad, Gleizarov Evgeny, Mahajna Ahmad
Department of General Surgery, Laboratory of Shock and Trauma Research, Rambam Medical Center and, The Bruce Rappaport Faculty of Medicine, Technion-Institute of Technology, P.O. Box 9602, 31096, Haifa, Israel.
The Department of Urology, Rambam Medical Center and, The Bruce Rappaport Faculty of Medicine, Technion-Institute of Technology, Haifa, Israel.
BMC Res Notes. 2019 Jun 8;12(1):321. doi: 10.1186/s13104-019-4353-6.
Our study aims to emphasize the novelty of female rats in regard to their hemodynamic changes in response to abdominal compartment syndrome. A group of 64 rats was randomly divided into 4 subgroups for each gender. Except for the control, intra-abdominal pressure was increased to 10, 20, 30 mmHg. Survival time, mean arterial pressure, pH and lactate were determined at different time intervals.
As IAP was 20 mmHg, a statistically difference was seen between the male group and the female group starting from 15 min (126 ± 9.7 mmHg, 124 ± 14.7 mmHg respectively, p < 0.02) and lasting 2 h. At 30 mmHg, a statistically difference was seen between 30 to 60 min (p < 0.05). Only group 2 presented results with statistical power both at 30 and at 60 min concerning pH (p = 0.003, p < 0.001 respectively). In the lactate measurements at IAP of 10 mmHg, at 60 min male lactate level was 3.93 ± 1.13 and 2.25 ± 0.33 in female rats (p = 0.034). Female rats that were subjected to IAP of 20 mmHg and 30 mmHg had significantly better survival than male rats that were subjected to the same pressure (p < 0.05 and p < 0.01, respectively). We concluded that female rats have better preserved their hemodynamic and metabolic parameters during ACS than male rats.
我们的研究旨在强调雌性大鼠在应对腹腔间隔室综合征时血流动力学变化方面的新颖性。一组64只大鼠按性别随机分为4个亚组。除对照组外，将腹内压分别升高至10、20、30 mmHg。在不同时间间隔测定存活时间、平均动脉压、pH值和乳酸水平。
当腹内压为20 mmHg时，从15分钟开始（分别为126±9.7 mmHg和124±14.7 mmHg，p<0.02），雄性组和雌性组之间出现统计学差异，并持续2小时。当腹内压为30 mmHg时，在30至60分钟之间出现统计学差异（p<0.05）。只有第2组在30分钟和60分钟时的pH值结果具有统计学意义（分别为p = 0.003，p<0.001）。在腹内压为10 mmHg时的乳酸测量中，60分钟时雄性大鼠的乳酸水平为3.93±1.13，雌性大鼠为2.25±0.33（p = 0.034）。腹内压为20 mmHg和30 mmHg的雌性大鼠的存活率明显高于相同压力下的雄性大鼠（分别为p<0.05和p<0.01）。我们得出结论，在腹腔间隔室综合征期间，雌性大鼠比雄性大鼠更好地维持了其血流动力学和代谢参数。
