Regul Toxicol Pharmacol. 2019 Oct;107:104389. doi: 10.1016/j.yrtph.2019.05.014. Epub 2019 Jun 6.
On the basis of the safety assessment carried out using a conservative approach, the SCCS considers the use of Acetylated Vetiver Oil (AVO) with 1% alpha-tocopherol as a fragrance ingredient in cosmetic leave-on and rinse-off type products safe at the concentrations proposed by IFRA. Acetylated Vetiver Oil (AVO) contains some constituents that belong to the chemical group of aldehydes and ketones that are known to be reactive towards biological entities, such as DNA and proteins. However, the overall health risk of such components is likely to be negligible at the concentrations intended to be used in cosmetics products. The SCCS has noted that Acetylated Vetiver Oil (AVO) is a moderate skin sensitiser in test animals. Considering the results of the HRIPT study and the fact that AVO has been used for years in cosmetics without evidence of sensitising potential, it is unlikely that AVO would be causing contact allergy in humans. Inhalation toxicity of Acetylated Vetiver Oil (AVO) was not assessed in this Opinion because no data were provided. Assessment of the inhalation risk would be needed if Acetylated Vetiver Oil (AVO) was intended to be used in sprayable products.
基于保守方法进行的安全评估，SCCS 认为在 IFRA 建议的浓度下，将乙酰化香根油（AVO）与 1%α-生育酚一起用作化妆品免洗和冲洗型产品中的香料成分是安全的。乙酰化香根油（AVO）含有一些属于醛酮化学基团的成分，已知这些成分对生物实体（如 DNA 和蛋白质）具有反应性。然而，在预期用于化妆品产品的浓度下，此类成分的总体健康风险可能微不足道。SCCS 注意到，乙酰化香根油（AVO）在试验动物中是一种中度皮肤致敏剂。考虑到 HRIPT 研究的结果以及 AVO 多年来在化妆品中使用而没有潜在致敏性的证据，AVO 不太可能在人类中引起接触过敏。在本意见中，没有评估乙酰化香根油（AVO）的吸入毒性，因为没有提供数据。如果乙酰化香根油（AVO）拟用于喷雾产品，则需要评估吸入风险。
