Neilan B A, Taddeini L
J Am Geriatr Soc. 1979 Apr;27(4):170-3. doi: 10.1111/j.1532-5415.1979.tb06441.x.
The numbers and percentages of active rosette-forming T cells were measured in two age groups, to assess the effects of aging. The study included 21 healthy persons in the 20--40 age group and 25 persons without major disease in the 60--85 age group. In the younger subjects the number of rosette-forming cells (RFC) averaged 1430 +/- 463/cu mm (mean and S.D.), a count not significantly different from that in the older subjects (1443 +/- 398/cu mm). Likewise, the active RFC count in the 20--40 age group (526 +/- 185/cu mm) and that in the 60--85 age group (558 +/- 197/cu mm) were not significantly different. There was no difference for the percentage total RFC (young 78 +/- 4%, elderly 78 +/- 6%) or the percentage active RFC (young 29 +/- 7%, elderly 30 +/- 6%). For the total lymphocyte count or the B lymphocyte count, there was no difference between the two groups of subjects. It is concluded that T lymphocytes, measured as total and active rosette-forming cells, are not decreased in healthy older persons.
为评估衰老的影响，对两个年龄组中具有活性的形成玫瑰花结的T细胞数量及百分比进行了测量。该研究纳入了21名年龄在20至40岁的健康个体以及25名年龄在60至85岁且无重大疾病的个体。在较年轻的受试者中，形成玫瑰花结的细胞（RFC）数量平均为1430±463/立方毫米（均值及标准差），这一计数与较年长受试者（1443±398/立方毫米）的计数无显著差异。同样，20至40岁年龄组的活性RFC计数（526±185/立方毫米）与60至85岁年龄组的活性RFC计数（558±197/立方毫米）也无显著差异。总RFC百分比（年轻组78±4%，老年组78±6%）或活性RFC百分比（年轻组29±7%，老年组30±6%）没有差异。对于两组受试者的总淋巴细胞计数或B淋巴细胞计数，也没有差异。得出的结论是，以总形成玫瑰花结细胞和活性形成玫瑰花结细胞来衡量，健康老年人的T淋巴细胞并未减少。
