老年人及阿尔茨海默病患者的免疫学参数
Immunological parameters in the aged and in Alzheimer's disease.
作者信息
Macdonald S M, Goldstone A H, Morris J E, Exton-Smith A N, Callard R E
出版信息
Clin Exp Immunol. 1982 Jul;49(1):123-8.
Peripheral blood from patients with Alzheimer's disease, elderly normal subjects and young (normal subjects) was examined with respect to leucocyte phenotypes and proliferative responses to lectins. Whole blood cell analysis showed that the neutrophil count was similar in all three groups. However, the lymphocyte count was depressed in the Alzheimer group. The monocyte count was reduced in the healthy aged and further reduced in the Alzheimer group. Analysis of peripheral blood mononuclear cells showed no change in the proportion of E+ cells, total T determined with the monoclonal antibody UCHT1 (similar to OKT3) and the T cell subsets: active E and T dot (discrete esterase staining). However, the proportion of T cells bearing the antigen detected by UCHT3 monoclonal antibody (similar to Leu 1 and OKT1) was reduced in the healthy aged and further reduced in the Alzheimer group. Proliferative responses to PHA, Con A, PA, and PWM were similarly depressed in both the aged and Alzheimer groups.
对阿尔茨海默病患者、老年正常受试者和年轻（正常）受试者的外周血进行白细胞表型及对凝集素增殖反应的检测。全血细胞分析显示，三组的中性粒细胞计数相似。然而，阿尔茨海默病组的淋巴细胞计数降低。健康老年人的单核细胞计数减少，而阿尔茨海默病组的单核细胞计数进一步减少。外周血单个核细胞分析显示，E+细胞比例、用单克隆抗体UCHT1（类似于OKT3）测定的总T细胞以及T细胞亚群：活性E细胞和T点（离散酯酶染色）均无变化。然而，UCHT3单克隆抗体（类似于Leu 1和OKT1）检测到的携带抗原的T细胞比例在健康老年人中降低，在阿尔茨海默病组中进一步降低。老年人和阿尔茨海默病组对PHA、Con A、PA和PWM的增殖反应同样受到抑制。
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