Middelkoop O P, Veldhuizen R W, Scheper R J
Int Arch Allergy Appl Immunol. 1976;52(1-4):412-6. doi: 10.1159/000231708.
The influence of age and sex on the lymphocyte count and numbers of E and EAC rosette-forming cells (RFC) was investigated using peripheral blood of healthy donors. In the female donors we found a lower total lymphocyte count and percentage of EAC RFC than in male donors. The percentage and total number of E RFC appeared to be low in younger donors. Total lymphocyte count and numbers of E and EAC RFC were investigated in untreated and treated patients with advanced solid tumors and in patients with untreated malignant lymphomas. The lymphocyte count in all these groups was decreased, but the E/EAC RFC ratio was normal, except in the group with untreated solid tumors, where we found an increased percentage of E RFC. It is suggested that in these patients a nonspecific impairment of bone marrow function might be expressed in numbers of peripheral T and B cells.
利用健康供血者的外周血，研究了年龄和性别对淋巴细胞计数以及E和EAC玫瑰花结形成细胞（RFC）数量的影响。在女性供血者中，我们发现其总淋巴细胞计数和EAC RFC百分比均低于男性供血者。E RFC的百分比和总数在较年轻的供血者中似乎较低。对晚期实体瘤未治疗和已治疗的患者以及未治疗的恶性淋巴瘤患者的总淋巴细胞计数以及E和EAC RFC数量进行了研究。所有这些组的淋巴细胞计数均降低，但E/EAC RFC比值正常，不过在未治疗的实体瘤组中除外，在该组中我们发现E RFC百分比增加。提示在这些患者中，骨髓功能的非特异性损害可能在外周T和B细胞数量上表现出来。
