Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.
Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan.
Environ Health Prev Med. 2019 Jun 10;24(1):42. doi: 10.1186/s12199-019-0796-6.
We reported that human T cell leukemia virus 1 (HTLV-1) infection is positively associated with atherosclerosis. Recent evidence has revealed a close association of periodontitis with atherosclerosis, endothelial dysfunction, and disruption of the microcirculation. However, the association between HTLV-1 and advanced periodontitis has not been investigated to date. Since hematopoietic activity is closely linked to endothelial maintenance activity and is known to decline with age, we hypothesized that the state of hematopoietic activity influenced the association between HTLV-1 and advanced periodontitis in elderly participants.
A cross-sectional study was performed including 822 elderly participants aged 60-99 years who participated in a dental health check-up. Advanced periodontitis was defined as a periodontal pocket ≥ 6.0 mm. Participants were classified as having low or high hematopoietic activity according to the median values of reticulocytes.
HTLV-1 infection was positively related to advanced periodontitis among participants with lower hematopoietic activity (lower reticulocyte count), but not among participants with higher hematopoietic activity (higher reticulocyte count). The adjusted odds ratio (95% confidence interval) considering potential confounding factors was 1.92 (1.05-3.49) for participants with a lower reticulocyte count and 0.69 (0.35-1.36) for participants with a higher reticulocyte count.
Among elderly participants, the association between HTLV-1 infection and advanced periodontitis is influenced by hematopoietic activity. Since hematopoietic activity is associated with endothelial maintenance, these findings provide an efficient tool for clarifying the underlying mechanism of the progression of periodontitis among elderly participants.
我们曾报道人类 T 细胞白血病病毒 1（HTLV-1）感染与动脉粥样硬化呈正相关。最近的证据表明，牙周炎与动脉粥样硬化、内皮功能障碍和微循环破坏密切相关。然而，迄今为止，尚未研究 HTLV-1 与晚期牙周炎之间的关联。由于造血活性与内皮维持活性密切相关，并且已知其随年龄增长而下降，我们假设造血活性状态会影响老年参与者中 HTLV-1 与晚期牙周炎之间的关联。
进行了一项横断面研究，纳入了 822 名年龄在 60-99 岁之间参加牙齿健康检查的老年参与者。晚期牙周炎定义为牙周袋≥6.0mm。根据网织红细胞的中位数将参与者分为低或高造血活性。
在造血活性较低（网织红细胞计数较低）的参与者中，HTLV-1 感染与晚期牙周炎呈正相关，但在造血活性较高（网织红细胞计数较高）的参与者中则无此关联。考虑到潜在混杂因素的调整后比值比（95%置信区间）分别为低网织红细胞计数的参与者为 1.92（1.05-3.49），高网织红细胞计数的参与者为 0.69（0.35-1.36）。
在老年参与者中，HTLV-1 感染与晚期牙周炎之间的关联受造血活性的影响。由于造血活性与内皮维持有关，这些发现为阐明老年参与者牙周炎进展的潜在机制提供了有效的工具。
