Laboratory of Neuropathology Modeling, Neurogenetics of Social Behavior Sector, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
Biomed Res Int. 2019 Apr 28;2019:7276389. doi: 10.1155/2019/7276389. eCollection 2019.
Chronic agonistic interactions promote the development of experimental psychopathologies in animals: a depression-like state in chronically defeated mice and the pathology of aggressive behavior in the mice with repeated wins. The abundant research data indicate that such psychopathological states are associated with significant molecular and cellular changes in the brain. This paper aims to study the influence of a 20-day period of agonistic interactions on the expression patterns of collagen family genes encoding the proteins which are basic components of extracellular matrix (ECM) in different brain regions of mice using the RNA-Seq database. Most of differentially expressed collagen genes were shown to be upregulated in the hypothalamus and striatum of chronically aggressive and defeated mice and in the hippocampus of defeated mice, whereas downregulation of collagen genes was demonstrated in the ventral tegmental areas in both experimental groups. Aberrant expression of collagen genes induced by chronic agonistic interactions may be indicative of specific ECM defects in the brain regions of mice with alternative social experience. This is the first study demonstrating remodeling of ECM under the development of experimental disorders.
慢性战败小鼠出现类似抑郁状态，而反复获胜的小鼠出现攻击行为病理学。大量研究数据表明，这种精神病理状态与大脑中的显著分子和细胞变化有关。本文旨在使用 RNA-Seq 数据库研究 20 天争战性相互作用对不同脑区胶原家族基因表达模式的影响，这些基因编码细胞外基质（ECM）的基本成分的蛋白质。研究表明，在慢性攻击和战败小鼠的下丘脑和纹状体以及战败小鼠的海马体中，大多数差异表达的胶原基因上调，而在两组实验的腹侧被盖区则下调。慢性争战性相互作用引起的胶原基因异常表达可能表明具有不同社会经验的小鼠脑区存在特定的 ECM 缺陷。这是第一项证明 ECM 在实验性疾病发展过程中发生重塑的研究。
