Zhang Sheng, Young Phelps Shannon, Brent Hill Melissa, Ruiz Rafael
Adhezion Biomedical, Hudson, NC.
PerkinElmer Inc, Waltham, MA.
Wounds. 2019 Jul;31(7):166-172. Epub 2019 May 31.
The purpose of this study is to introduce a wound closure testing method that reproduces a pulling or stretching force, leading to more accurate supporting data for clinicians to select the proper product when closing a low- or high-tension incision in conjunction with deep dermal sutures.
Incisions were made in the center of 70 prepared porcine skin samples. They were cleaned with isopropanol and wiped dry before applying the adhesive, as per each respective manufacturer's instructions. A tensile tester was used to pull the incisions apart and record each wound closure maximum disruption force. A paired t test assuming unequal variances was performed on the data.
This new wound closure test method was determined to be more advantageous when compared with previous methods in terms of approximation incision, approximation of clinical scenario, approximation directional force experienced by incision, number of steps, sample preparation time, and equipment needed. One specific 2-octyl cyanoacrylate topical skin adhesive product was revealed to have statistically significantly higher wound closure strength than most of the investigated adhesives. That topical skin adhesive exhibited a higher mean strength than all other cyanoacrylate tissue adhesives tested in this study.
The study indicates this wound closure test has the potential to be an ideal testing method for predicting the strength of a wound-sealing adhesive subjected to a pulling or stretching force. The topical skin adhesive that demonstrated the highest mean strength of the 7 cyanoacrylate adhesive products tested potentially could be the optimal wound closure device for low- or high-tension incisions in conjunction with deep dermal sutures.
本研究的目的是介绍一种伤口闭合测试方法，该方法可再现拉力或拉伸力，从而为临床医生在结合深层真皮缝线闭合低张力或高张力切口时选择合适的产品提供更准确的支持数据。
在70个制备好的猪皮样本中心制作切口。按照各制造商的说明，先用异丙醇清洁切口，然后擦干，再涂抹粘合剂。使用拉伸试验机拉开切口并记录每个伤口闭合的最大破坏力。对数据进行了假设方差不等的配对t检验。
与以往方法相比，这种新的伤口闭合测试方法在近似切口、临床场景近似度、切口所受方向力近似度、步骤数量、样本制备时间和所需设备方面更具优势。一种特定的2-辛基氰基丙烯酸酯局部皮肤粘合剂产品在统计学上显示出比大多数研究的粘合剂具有显著更高的伤口闭合强度。该局部皮肤粘合剂的平均强度高于本研究中测试的所有其他氰基丙烯酸酯组织粘合剂。
该研究表明，这种伤口闭合测试有可能成为预测伤口密封粘合剂在拉力或拉伸力作用下强度的理想测试方法。在测试的7种氰基丙烯酸酯粘合剂产品中，显示出最高平均强度的局部皮肤粘合剂可能是结合深层真皮缝线用于低张力或高张力切口的最佳伤口闭合装置。
