Bernard Daphné, Sultan Ariane, Bouzakri Karim
Centre Européen d'Etude du Diabète, Research Unit of Strasbourg University Diabetes and Therapeutics, UR7294, 67200 Strasbourg, France.
Diabetology Nutrition Department, Montpellier University Hospital, 34090 Montpellier, France.
Int J Mol Sci. 2025 Aug 23;26(17):8182. doi: 10.3390/ijms26178182.
For a few decades, Type 2 Diabetes (T2D) has been recognized as a worldwide public health issue. T2D relies on systemic insulin resistance leading to Beta cell dysfunction. Nowadays, lifestyle modifications, such as improving eating habits and increasing physical activity, represent the first recommendations for managing T2D. Physical exercise, as a structured physical activity, is now considered as a non-pharmacological treatment with a wide range of beneficial effects, especially for people living with T2D. The review intends to summarize the current knowledge of physical exercise benefits in a context of T2D: from "unwanted" adipose tissue reduction to Beta cell health improvement. Moreover, we try to suggest an underlying mechanism explaining physical exercise beneficial effects in the context of T2D focusing on exerkines, molecules secreted in response to physical exercise. With this review, we highlight the beneficial impact of post-exercise secretions on Beta cell health and encourage research to continue in this direction. Identifying new exerkines with beneficial effects in the context of T2D could represent a promising approach for managing metabolic diseases.
几十年来，2型糖尿病（T2D）一直被视为一个全球性的公共卫生问题。T2D依赖于导致β细胞功能障碍的全身胰岛素抵抗。如今，生活方式的改变，如改善饮食习惯和增加体育活动，是管理T2D的首要建议。体育锻炼作为一种有组织的身体活动，现在被认为是一种具有广泛有益效果的非药物治疗方法，特别是对于T2D患者。这篇综述旨在总结在T2D背景下体育锻炼益处的当前知识：从减少“多余”的脂肪组织到改善β细胞健康。此外，我们试图提出一种潜在机制，解释在T2D背景下体育锻炼的有益效果，重点关注运动因子，即运动后分泌的分子。通过这篇综述，我们强调运动后分泌物对β细胞健康的有益影响，并鼓励在这个方向上继续开展研究。识别在T2D背景下具有有益作用的新运动因子可能是管理代谢性疾病的一种有前景的方法。
