Liu Changjin, Wen Jing, Xiang Jialin, Ouyang Xuhong, Yang Yan, Lu Wei, Wang Jianwei, Huang Jian, Min Xun
1 Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University, Guizhou, China.
2 Department of Medical Imaging, Affiliated Hospital of Zunyi Medical University, Guizhou, China.
J Int Med Res. 2019 Jul;47(7):3151-3159. doi: 10.1177/0300060519855575. Epub 2019 Jun 12.
This study aimed to investigate serum levels of the cystatin C (CysC)/creatinine (Cr) ratio and renal serum markers (CysC, Cr, urea, and uric acid [UA]) for different ages and by sex. We also aimed to establish pediatric reference intervals for the serum CysC/Cr ratio.
Serum samples were collected from 4765 healthy children (0–18 years old). Serum markers of renal function were measured, and the CysC/Cr ratio of each participant was calculated and statistically analyzed.
The renal marker CysC did not substantially change after 1 year old. Cr, urea, and UA levels generally increased with age. However, the serum CysC/Cr ratio steadily decreased with age. The CysC/Cr ratio showed significant differences in age among all age groups and varied with sex, except for in the 1 to 6-year-old groups. The overall serum CysC/Cr ratio in girls was higher than that in boys.
Reference intervals of the serum CysC/Cr ratio in the pediatric population were established. These intervals need to be partitioned by age and sex.
本研究旨在调查不同年龄和性别的胱抑素C（CysC）/肌酐（Cr）比值及肾脏血清标志物（CysC、Cr、尿素和尿酸[UA]）的血清水平。我们还旨在建立儿童血清CysC/Cr比值的参考区间。
收集4765名健康儿童（0至18岁）的血清样本。检测肾功能的血清标志物，计算并统计分析每位参与者的CysC/Cr比值。
1岁以后肾脏标志物CysC变化不大。Cr、尿素和UA水平一般随年龄增长而升高。然而，血清CysC/Cr比值随年龄稳步下降。除1至6岁组外，CysC/Cr比值在各年龄组间存在显著年龄差异且随性别不同而变化。女孩的总体血清CysC/Cr比值高于男孩。
建立了儿童人群血清CysC/Cr比值的参考区间。这些区间需要按年龄和性别进行划分。
