β地中海贫血特征中并存的缺铁/铁过载

Co-existing iron deficiency/overload in beta-thalassemia trait.

作者信息

Yousafzai Yasar Mehmood, Wahid Qurat Ul Ain, Khan Shahtaj, Mir Awal, Khan Arshad, Raziq Fazle

机构信息

Institute of Basic Medical Sciences, Khyber Medical University.

Institute of Cancer Sciences, University of Glasgow, UK.

出版信息

J Pak Med Assoc. 2019 Jun;69(6):806-810.

PMID:31189286

Abstract

OBJECTIVE

To identify the co-existence of iron deficiency and iron overload in individuals with beta thalassaemia trait.

METHODS

The cross-sectional study was conducted at Rehman Medical Institute and Khyber Medical University, Peshawar, Pakistan, September 1, 2015, to December 31, 2017, and comprised individuals with hypochromic microcytic blood picture. Haemoglobin electrophoresis was performed on their blood samples. Serum ferritin levels of subjects with Haemoglobin Subunit Alpha 2 levels between 3.5% and 7% were checked. Data were analysed using analysed using GraphPad Prism v6.

RESULTS

Of the 292 subjects, 159(54.5%) were males and 133(45.5%) were females. Of these, 240 (82.2%) were anaemic and 52 (17.8%) had haemoglobin within the normal range. Serum ferritin level of 55(18.8%) subjects was low and 207(70.9%) were iron-replete. Notably, 30(10.3%) subjects had serum ferritin levels higher than the reference range, and this was more common among adults (p<0.001).

CONCLUSIONS

Ferritin levels in beta thalassaemia trait can be low, normal or higher than the normal values..

摘要

目的

确定β地中海贫血特征个体中缺铁与铁过载的共存情况。

方法

这项横断面研究于2015年9月1日至2017年12月31日在巴基斯坦白沙瓦的雷曼医学院和开伯尔医科大学进行，纳入小细胞低色素性血象的个体。对其血样进行血红蛋白电泳。检查血红蛋白亚基α2水平在3.5%至7%之间的受试者的血清铁蛋白水平。数据使用GraphPad Prism v6进行分析。

结果

292名受试者中，159名（54.5%）为男性，133名（45.5%）为女性。其中，240名（82.2%）贫血，52名（17.8%）血红蛋白在正常范围内。55名（18.8%）受试者血清铁蛋白水平低，207名（70.9%）铁储备充足。值得注意的是，30名（10.3%）受试者血清铁蛋白水平高于参考范围，这在成年人中更常见（p<0.001）。