卡尔西奥林A，一种来自于……的新木脂素。 （原文句子不完整，翻译可能不太准确，需结合完整原文进一步完善）
Kalshiolin A, new lignan from .
作者信息
Wang Guo-Kai, Jin Wen-Fang, Zhang Nan, Wang Gang, Cheng Yung-Yi, Morris-Natschke Susan L, Goto Masuo, Zhou Zhong-Yu, Liu Jin-Song, Lee Kuo-Hsiung
机构信息
School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica, Hefei 230027, China.
Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, USA.
出版信息
J Asian Nat Prod Res. 2020 May;22(5):489-495. doi: 10.1080/10286020.2019.1592164. Epub 2019 Jun 13.
The Asian plant has been used as food and ethnologic medicine for over a thousand years. In this study, we isolated and identified one new lignan, kalshiolin A (), and 12 known lignans (). The structures were characterized by the comprehensive analyses of spectroscopic data (HR-ESI-MS, IR, 1D, and 2D-NMR) and the absolute configuration of was determined from ECD calculations. The new compound was also screened for cytotoxic activity but did not show significant potency (IC 35.9-43.3 M) against A549, MDA-MB-231, MCF7, KB, and KB-VIN cell lines.
这种亚洲植物作为食物和民族药物已有一千多年的历史。在本研究中，我们分离并鉴定了一种新的木脂素，卡尔西奥林A（），以及12种已知的木脂素（）。通过光谱数据（高分辨电喷雾电离质谱、红外光谱、一维和二维核磁共振）的综合分析对其结构进行了表征，并通过电子圆二色计算确定了的绝对构型。还对新化合物进行了细胞毒性活性筛选，但对A549、MDA-MB-231、MCF7、KB和KB-VIN细胞系未显示出显著活性（IC 35.9-43.3 μM）。
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