Galetti Renata, Penha Filho Rafael Antonio Casarin, Ferreira Joseane Cristina, Varani Alessandro M, Darini Ana Lúcia Costa
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), Jaboticabal, Brazil.
Infect Drug Resist. 2019 May 7;12:1029-1033. doi: 10.2147/IDR.S196411. eCollection 2019.
We describe the mobilome of 40A isolated from poultry, consisting of four different plasmids, p46_40A (IncX1, 45,869 bp), p80_40A (non-typable, 79,635 bp), p150_40A (IncI1-ST1, 148,340 bp) and p280_40A (IncHI2A-ST2, 279,537 bp). The mobilome-40A carries a blend of several different resistance and virulence genes, heavy metal tolerance operons and conjugation system. This mobilome 40A is a perfect tool to preserve and disseminate antimicrobial resistance and makes the bacterial isolate incredibly adapted to survive under constant antimicrobial pressure.
我们描述了从家禽中分离出的40A的可移动基因组，它由四种不同的质粒组成，即p46_40A（IncX1，45,869 bp）、p80_40A（不可分型，79,635 bp）、p150_40A（IncI1-ST1，148,340 bp）和p280_40A（IncHI2A-ST2，279,537 bp）。可移动基因组-40A携带多种不同的抗性和毒力基因、重金属耐受操纵子以及接合系统。这种可移动基因组40A是保存和传播抗菌抗性的完美工具，使该细菌分离株能够在持续的抗菌压力下极其适应地存活。
