Sabater-Martos Marta, Sigmund Irene Katharina, Loizou Constantinos, McNally Martin
The Bone Infection Unit, Nuffield Orthopaedic Centre. Windmill Rd, Headington. Oxford OX3 7HE, Oxford University Hospitals Foundation NHS Trust, Oxford, UK.
Department of Orthopaedics and Trauma Surgery. Hospital Universitari Germans Trias i Pujol, Badalona. Carretera del Canyet s/n, 08916 Badalona, Spain.
J Bone Jt Infect. 2019 May 21;4(3):146-154. doi: 10.7150/jbji.34452. eCollection 2019.
Calcaneal osteomyelitis is an uncommon and challenging condition. In this systematic review we aim to analyse the outcomes from concomitant use of bone debridement and soft tissue management for patients diagnosed with calcaneal osteomyelitis. A complete computerised and comprehensive literature search of Pubmed and Cochrane database was undertaken from January 2000 to October 2018. During the review, studies were screened for information about the surgical and antimicrobial treatment, the complications, the reinfection rate and the functional outcome of patients with calcaneal osteomyelitis. Of the 20 eligible studies included, seven (35%) described bone treatment only, six (30%) soft tissue treatment only, five (25%) soft tissue and bone treatment, and two (10%) focused on prognostic factors and differences in outcomes between diabetic and non-diabetic patients. In the studies with bone treatment only, infection recurrence ranged from 0 to 35% and the amputation rate from 0 to 29%. If soft tissue coverage was also needed, both the reinfection rate and amputation rate ranged from 0 to 24%. Studies presenting the functional status generally showed preservation or even improvement of the preoperative ambulatory status. Calcaneal osteomyelitis is difficult to treat. A multidisciplinary approach involving orthopaedic surgeons, plastic surgeons and infectious disease physicians is preferred. The heterogenicity of studies has hindered the development of agreed treatment protocols, which would be useful in clinical practice.
跟骨骨髓炎是一种罕见且具有挑战性的病症。在本系统评价中,我们旨在分析对于诊断为跟骨骨髓炎的患者同时进行骨清创和软组织处理的结果。从2000年1月至2018年10月,对PubMed和Cochrane数据库进行了全面的计算机化文献检索。在评价过程中,筛选研究以获取有关跟骨骨髓炎患者的手术和抗菌治疗、并发症、再感染率及功能结局的信息。纳入的20项合格研究中,7项(35%)仅描述了骨治疗,6项(30%)仅描述了软组织治疗,5项(25%)描述了软组织和骨治疗,2项(10%)关注预后因素以及糖尿病和非糖尿病患者结局的差异。在仅进行骨治疗的研究中,感染复发率为0至35%,截肢率为0至29%。如果还需要软组织覆盖,再感染率和截肢率均为0至24%。呈现功能状态的研究通常显示术前行走状态得以保留甚至改善。跟骨骨髓炎难以治疗。首选由骨科医生、整形外科医生和传染病医生组成的多学科方法。研究的异质性阻碍了达成一致的治疗方案的制定,而这些方案在临床实践中会很有用。