内脏脂肪堆积与 2 型糖尿病患者哮喘有关。
Visceral Fat Accumulation Is Associated with Asthma in Patients with Type 2 Diabetes.
机构信息
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Department of Cardiology, Oita Red Cross Hospital, Oita, Japan.
出版信息
J Diabetes Res. 2019 May 2;2019:3129286. doi: 10.1155/2019/3129286. eCollection 2019.
OBJECTIVE
The number of patients with type 2 diabetes has increased in Japan, and type 2 diabetes has attracted attention as a risk factor for asthma. However, the risk factors for the development of asthma in patients with type 2 diabetes have not been determined. This study was performed to clarify whether visceral fat accumulation (VFA) and insulin resistance are risk factors for the development of asthma in patients with type 2 diabetes.
MATERIALS AND METHODS
A cross-sectional study was conducted. The study group comprised 15 patients with type 2 diabetes with asthma, and the control group comprised 145 patients with type 2 diabetes without asthma. Their fat distribution was evaluated by measuring the VFA by abdominal computed tomography at the umbilical level. Their glucose status was assessed by measuring the fasting plasma glucose (FPG) concentration, fasting immunoreactive insulin concentration, homeostasis model assessment (HOMA) index, and hemoglobin A1c concentration.
RESULTS
Among patients with type 2 diabetes, VFA was significantly greater in patients with asthma than those without asthma ( < 0.0001). The FPG concentration, fasting immunoreactive insulin concentration, and HOMA index were higher in patients with asthma than those without asthma ( < 0.05, < 0.0001, and < 0.0001, respectively). Multiple logistic regression analysis showed that VFA and the HOMA index were significantly associated with asthma in patients with type 2 diabetes (odds ratio, 1.78; 95% confidence interval, 1.31-3.89; = 0.0115 and odds ratio, 3.65; 95% confidence interval, 1.37-7.85; = 0.0078, respectively).
CONCLUSIONS
Our data suggest that VFA and insulin resistance are associated with the development of asthma in patients with type 2 diabetes.
目的
日本 2 型糖尿病患者人数增加，2 型糖尿病已成为哮喘的一个危险因素。然而，2 型糖尿病患者发生哮喘的危险因素尚未确定。本研究旨在阐明内脏脂肪堆积（VFA）和胰岛素抵抗是否是 2 型糖尿病患者发生哮喘的危险因素。
材料和方法
进行了一项横断面研究。研究组包括 15 例 2 型糖尿病伴哮喘患者，对照组包括 145 例 2 型糖尿病无哮喘患者。通过在脐水平进行腹部 CT 测量 VFA 评估他们的脂肪分布。通过测量空腹血糖（FPG）浓度、空腹免疫反应性胰岛素浓度、稳态模型评估（HOMA）指数和糖化血红蛋白（HbA1c）浓度评估他们的血糖状态。
结果
在 2 型糖尿病患者中，哮喘患者的 VFA 明显大于无哮喘患者（<0.0001）。哮喘患者的 FPG 浓度、空腹免疫反应性胰岛素浓度和 HOMA 指数均高于无哮喘患者（<0.05、<0.0001 和<0.0001）。多因素 logistic 回归分析显示，VFA 和 HOMA 指数与 2 型糖尿病患者的哮喘显著相关（比值比，1.78；95%置信区间，1.31-3.89；=0.0115 和比值比，3.65；95%置信区间，1.37-7.85；=0.0078）。
结论
我们的数据表明，VFA 和胰岛素抵抗与 2 型糖尿病患者哮喘的发生有关。
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