Ip C, White G
Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, NY 14263.
Carcinogenesis. 1987 Dec;8(12):1763-6. doi: 10.1093/carcin/8.12.1763.
The chemopreventive efficacies of selenate, selenite, selenium dioxide, selenomethionine and selenocystine were examined during the promotion phase of carcinogenesis in the 7,12-dimethylbenz[a]anthracene-induced mammary tumor model in rats. Each agent was added to the diet at a final concentration of 3 p.p.m. selenium. In general there was no significant difference in the potency of these five selenium compounds in inhibiting the development of mammary tumors. The interaction of vitamin E (500 p.p.m.) with either selenite or selenomethionine was further characterized in a second carcinogenesis study. Results of this experiment suggested that vitamin E enhanced the protective effect of selenite but not that of selenomethionine. In an attempt to explore the synergistic mechanism of selenium and vitamin E, the effects of these two agents on mitogen-induced blastogenesis and natural killer cytotoxic activity were also investigated. No consistent changes in these in vitro immune functions were detected resulting from supranutritional feeding of either selenite or vitamin E or both. The metabolism of inorganic versus organic selenium was discussed in relation to their role in the control of neoplastic growth as well as to their selective modulation by vitamin E.
在7,12-二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤模型的致癌促进阶段，研究了硒酸盐、亚硒酸盐、二氧化硒、硒代蛋氨酸和硒代半胱氨酸的化学预防效果。每种试剂以3 ppm硒的最终浓度添加到饮食中。一般来说，这五种硒化合物在抑制乳腺肿瘤发展的效力上没有显著差异。在第二项致癌研究中，进一步研究了维生素E（500 ppm）与亚硒酸盐或硒代蛋氨酸的相互作用。该实验结果表明，维生素E增强了亚硒酸盐的保护作用，但没有增强硒代蛋氨酸的保护作用。为了探索硒和维生素E的协同作用机制，还研究了这两种试剂对丝裂原诱导的母细胞生成和自然杀伤细胞细胞毒性活性的影响。通过超营养水平喂食亚硒酸盐或维生素E或两者，未检测到这些体外免疫功能有一致的变化。讨论了无机硒与有机硒的代谢与其在控制肿瘤生长中的作用以及维生素E对其选择性调节的关系。
