Ip C, Ip M M
Carcinogenesis. 1981;2(9):915-8. doi: 10.1093/carcin/2.9.915.
Mammary tumorigenesis induced in rats by 7,12-dimethylbenz[a]anthracene was markedly suppressed by combined dietary supplementation with sodium selenite and retinyl acetate; final tumor yield was reduced to 8% of control as compared with 51% and 36%, respectively, for selenium and retinyl acetate alone. A continuous intake of both agents was necessary to sustain the chemopreventive effect.
7,12-二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤发生，通过饮食中同时补充亚硒酸钠和醋酸视黄酯得到显著抑制；最终肿瘤发生率降至对照组的8%，而单独补充硒和醋酸视黄酯时，肿瘤发生率分别为51%和36%。持续摄入这两种物质对于维持化学预防效果是必要的。
