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一项针对成年智障人士的抗精神病药物停药结构化方案:康沃尔经验。

A structured programme to withdraw antipsychotics among adults with intellectual disabilities: The Cornwall experience.

机构信息

Cornwall Partnership NHS Foundation Trust, Truro, UK.

University of Exeter Medical School, Exeter, UK.

出版信息

J Appl Res Intellect Disabil. 2019 Nov;32(6):1389-1400. doi: 10.1111/jar.12635. Epub 2019 Jun 13.

Abstract

BACKGROUND

Antipsychotic medications are used among 19%-58% of adults with intellectual disabilities to manage challenging behaviour against the NICE guideline recommendations. Studies show that it is possible to completely withdraw antipsychotics in about one third of adults with intellectual disabilities and a dose reduction of 50% or more in another third.

METHOD

In Cornwall, over three years the present authors developed a structured pathway to withdraw antipsychotics among adults with intellectual disabilities which involved people with intellectual disabilities and their carers, GPs, community learning disability team members and pharmacists.

RESULTS

The present authors managed to withdraw antipsychotics totally among 46.5% (33/71) and reduced over 50% of dosage in another 11.3% (8/71) of adults with intellectual disabilities. At three months follow-up no one required hospital admission or change in placement.

CONCLUSION

It is possible to withdraw/reduce antipsychotics in a high proportion of adults with intellectual disabilities if a concerted effort is made involving all stakeholders from the outset.

摘要

背景

在有智力障碍的成年人中,19%-58%的人使用抗精神病药物来控制挑战性行为,这与 NICE 指南的建议相悖。研究表明,大约三分之一的有智力障碍的成年人可以完全停用抗精神病药物,另有三分之一的成年人可以减少 50%或更多的剂量。

方法

在康沃尔,作者们在三年的时间里开发了一种针对有智力障碍的成年人的抗精神病药物撤药结构化途径,涉及有智力障碍的个人及其照顾者、全科医生、社区学习障碍团队成员和药剂师。

结果

作者成功地使 46.5%(33/71)的成年人完全停用抗精神病药物,另有 11.3%(8/71)的成年人减少了超过 50%的剂量。在三个月的随访中,没有人需要住院或改变安置。

结论

如果从一开始就得到所有利益相关者的一致努力,就有可能使很大一部分有智力障碍的成年人停用/减少抗精神病药物。

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