Kloster B E, John P A, Miller L E, Rubin L A, Nelson D L, Blair D C, Tomar R H
Department of Pathology, SUNY Health Science Center at Syracuse 13210.
Clin Immunol Immunopathol. 1987 Dec;45(3):440-6. doi: 10.1016/0090-1229(87)90095-x.
Utilizing an enzyme-linked immunosorbent assay, we detected elevated serum levels of soluble interleukin 2 receptors (SIL-2R) in 73% of patients with acquired immunodeficiency syndrome (AIDS), 80% of AIDS-related complex patients, 78% of anti-HIV-positive lymphadenopathy syndrome patients, 85% of HIV-antibody-positive hemophiliacs, and 80% of anti-HIV-positive asymptomatic homosexual males, iv drug abusers, and heterosexual contacts. Of the subjects with no demonstrable antibody to HIV, 29% of hemophiliacs, 12% of adult homosexual males and iv drug abusers, and none of the patients with lymphadenopathy had elevated SIL-2R. Overall, only 5 of 40 antibody-negative "high-risk" individuals had SIL-2R values greater than the reference interval whereas 108 of 138 antibody-positive individuals had elevated values (chi 2 = 57.85, P less than 0.001).
利用酶联免疫吸附测定法，我们检测到73%的获得性免疫缺陷综合征（艾滋病）患者、80%的艾滋病相关综合征患者、78%的抗HIV阳性淋巴结病综合征患者、85%的HIV抗体阳性血友病患者以及80%的抗HIV阳性无症状同性恋男性、静脉注射吸毒者和异性接触者血清中可溶性白细胞介素2受体（SIL-2R）水平升高。在无明显HIV抗体的受试者中，29%的血友病患者、12%的成年同性恋男性和静脉注射吸毒者以及淋巴结病患者中无一例SIL-2R水平升高。总体而言，40名抗体阴性的“高危”个体中只有5人SIL-2R值高于参考区间，而138名抗体阳性个体中有108人值升高（卡方=57.85，P<0.001）。
