Islam Nazrul, Dmour Isra, Taha Mutasem O
Pharmacy Discipline, School of Clinical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, QLD 4000, Australia.
Institute of Health and Biomedical Innovation, QUT, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059, Australia.
Heliyon. 2019 May 15;5(5):e01684. doi: 10.1016/j.heliyon.2019.e01684. eCollection 2019 May.
Chitosan, a natural carbohydrate polymer, has long been investigated for drug delivery and medical applications due to its biodegradability, biocompatibility and low toxicity. The micro/nanoparticulate forms of chitosan are reported to enhance the efficiency of drug delivery with better physicochemical properties including improved solubility and bioavailability. This polymer is known to be biodegradable and biocompatible; however, crosslinked chitosan particles may not be biodegradable. Crosslinkers (e.g., tripolyphosphate and glutaraldehyde) are needed for efficient micro/nanoparticle formation, but it is not clear whether the resultant particles are biodegradable or able to release the encapsulated drug fully. To date, no studies have conclusively demonstrated the complete biodegradation or elimination of chitosan nanoparticles . Herein we review the synthesis and degradation mechanisms of chitosan micro/nanoparticles frequently used in drug delivery especially in pulmonary drug delivery to understand whether these nanoparticles are biodegradable.
壳聚糖是一种天然碳水化合物聚合物，由于其生物可降解性、生物相容性和低毒性，长期以来一直被用于药物递送和医学应用研究。据报道，壳聚糖的微/纳米颗粒形式具有更好的物理化学性质，包括改善的溶解性和生物利用度，从而提高了药物递送效率。已知这种聚合物具有生物可降解性和生物相容性；然而，交联的壳聚糖颗粒可能不可生物降解。高效形成微/纳米颗粒需要交联剂（如三聚磷酸钠和戊二醛），但尚不清楚所得颗粒是否可生物降解或能否完全释放包封的药物。迄今为止，尚无研究最终证明壳聚糖纳米颗粒能完全生物降解或消除。在此，我们综述了药物递送中尤其是肺部药物递送中常用的壳聚糖微/纳米颗粒的合成及降解机制，以了解这些纳米颗粒是否可生物降解。
Zotero 插件
