Huuskonen M S, Räsänen J A, Härkönen H, Asp S
Scand J Respir Dis. 1978;59(6):326-32.
Twenty immunological parameters were determined for 37 asbestos-exposed workers with no radiographic pulmonary fibrosis and 132 asbestosis patients, 37 of whom formed a matched referent group for the non-diseased workers. No clear differences between the matched groups were found for the autoantibodies tested, but the prevalence of autoantibodies was increased in both groups in comparison with the prevalence among Finnish blood donor candidates. This phenomenon may reflect a general immunological activity caused by asbestos dust, and this immunological activity may act as an adjuvant in immunisation. The patients revealed a high level of IgA, C3, C4 and alpha-1-antitrypsin. This result indicates that these factors may be related to the development of asbestosis, and could therefore be utilized in the evaluation of diffuse pulmonary fibrosis among workers with asbestos exposure.
对37名无放射学肺纤维化的石棉暴露工人和132名石棉肺患者测定了20项免疫学参数，其中37名石棉肺患者构成了未患病工人的匹配参照组。在检测的自身抗体方面，匹配组之间未发现明显差异，但与芬兰献血候选者中的患病率相比，两组自身抗体的患病率均有所增加。这种现象可能反映了石棉粉尘引起的一般免疫活性，而这种免疫活性可能在免疫接种中起佐剂作用。患者显示出高水平的IgA、C3、C4和α-1抗胰蛋白酶。这一结果表明，这些因素可能与石棉肺的发展有关，因此可用于评估石棉暴露工人的弥漫性肺纤维化。
