Huuskonen M S, Tiilikainen A, Alanko K
Br J Dis Chest. 1979 Jul;73(3):253-9.
HLA antigens were identified in 64 patients with radiographic asbestosis and 37 matched controls with equivalent asbestos exposure but no radiographic pulmonary fibrosis. A high prevalence of HLA-B18, B27 and Cw2 was found in the controls. This result might indicate that the possessors of these HLA antigens are thus protected from the development of diffuse pulmonary fibrosis from asbestos exposure. Signs of susceptibility were not demonstrated. The radiographic severity and progression of asbestosis were not associated with any of the HLA antigens tested.
在64例有放射学证据的石棉肺患者以及37例有同等石棉暴露但无放射学证据的肺纤维化的对照者中鉴定了HLA抗原。在对照者中发现HLA-B18、B27和Cw2的高流行率。这一结果可能表明，这些HLA抗原的携带者因此受到保护，免受石棉暴露导致的弥漫性肺纤维化的影响。未显示易感性迹象。石棉肺的放射学严重程度和进展与所检测的任何HLA抗原均无关联。
