Kunugita N, Mei N, Norimura T, Kagiya T V
Department of Radiation Biology and Health, University of Occupational and Environmental Health, Japan.
Indian J Exp Biol. 1996 Sep;34(9):838-41.
The effects of chemical modifiers of hypoxic radiosensitizer, a 3-nitrotriazole derivative AK-2123 (200 mg/kg) before treatment, and vasodilator of hydralazine (HDZ; 5.0 mg/kg) after treatment on tumor growth of SCCVII of mice were investigated in the radio-thermotherapy combined with mitomycin C (MMC; 2.0 mg/kg) or adriamycin (ADM; 3 mg/kg). The tumor treated by 10 Gy alone (tumor doubling time = 7.5 days), MMC alone (6.9 days), and hyperthermia (43 degrees C, 30 min; HT) alone (8.0 days) showed a slight growth delay (control: 5.6 days). Prolonged growth delay (23.2 days) was observed by MMC-radio-thermotherapy (MMC-10Gy/HT) than that (12.4 days) by 10 Gy/HT. The modification of MMC-radio-thermotherapy by HDZ administered between 10 Gy and HT (MMC-10 Gy/HDZ/HT) resulted in the significant prolongation of tumor growth delay (31.7 days). AK-2123 administration before this treatment, (MMC-AK-2123)-10 Gy/HDZ/HT), enhanced a further tumor growth delay (37.6 days) which is equal to that by 50 Gy alone and resulted in the highest dose modifying factor (DMF) of 5.2. While modification of ADM-radio-thermotherapy by AK-2123 and HDZ, (ADM-AK-2123)-10 Gy/HDZ/HT, gave the equal tumor growth delay to that by 30 Gy alone (DMF = 3.1). These high efficacies of radio-thermo-chemotherapy modified by AK-2123 and HDZ may be caused by tumor blood flow reduction.
研究了缺氧放射增敏剂的化学修饰剂（治疗前给予3-硝基三唑衍生物AK-2123，200mg/kg）以及治疗后给予血管舒张剂肼屈嗪（HDZ，5.0mg/kg）对小鼠SCCVII肿瘤生长的影响，该研究采用了与丝裂霉素C（MMC，2.0mg/kg）或阿霉素（ADM，3mg/kg）联合的放射热疗。单独接受10Gy照射（肿瘤倍增时间=7.5天）、单独接受MMC治疗（6.9天）以及单独接受热疗（43℃，30分钟；HT）（8.0天）的肿瘤显示出轻微的生长延迟（对照组：5.6天）。与10Gy/HT组（12.4天）相比，MMC-放射热疗（MMC-10Gy/HT）观察到更长的生长延迟（23.2天）。在10Gy照射和HT之间给予HDZ对MMC-放射热疗进行修饰（MMC-10Gy/HDZ/HT），导致肿瘤生长延迟显著延长（31.7天）。在此治疗前给予AK-2123，（MMC-AK-2123）-10Gy/HDZ/HT，进一步延长了肿瘤生长延迟（37.6天），这与单独给予50Gy照射的效果相当，并导致最高的剂量修正因子（DMF）为5.2。虽然AK-2123和HDZ对ADM-放射热疗进行修饰，（ADM-AK-2123）-10Gy/HDZ/HT，产生的肿瘤生长延迟与单独给予30Gy照射的效果相当（DMF=3.1）。AK-2123和HDZ修饰的放射热化疗的这些高效可能是由肿瘤血流减少引起的。
