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二尖瓣修复:迈向个性化瓣环

Mitral valve repair: moving towards a personalized ring.

作者信息

Pitsis Antonios, Kelpis Timotheos, Theofilogiannakos Efstratios, Tsotsolis Nikolaos, Boudoulas Harisios, Boudoulas Konstantinos Dean

机构信息

Department of Cardiac Surgery, St. Luke's Hospital, Thessaloniki, Greece.

Department of Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.

出版信息

J Cardiothorac Surg. 2019 Jun 13;14(1):108. doi: 10.1186/s13019-019-0926-7.

Abstract

BACKGROUND

Mitral valve repair with the use of an annuloplasty ring is the procedure of choice in patients with significant mitral regurgitation (MR) due to floppy mitral valve (FMV)/mitral valve prolapse (MVP). The mitral annular size, shape and motion may vary substantially among patients and thus, commercially available rings may not be suitable for each individual patient.

METHODS

A "personalized ring" (PR) was easily constructed in the operating room using a Dacron sheet and titanium ligating clips to custom fit to each individual mitral annulus shape and size. There were 127 patients with severe MR due to FMV/MVP that underwent mitral valve repair surgery; 58 patients received a PR and 69 patients received a commercial Carpentier-Edwards Physio II ring. The patient records were retrospectively analysed.

RESULTS

There were no surgical deaths. In-hospital length-of-stay and blood transfusions were not statistically different between the two groups. Mitral valve area was greater (p < 0.05) in the PR group (3.78 ± 0.22) compared to the Physio II ring group (3.13 ± 0.21). Mitral annular area changed from systole to diastole by 14.35% ± 3.28% in the PR group and did not change in the Physio II ring group (p < 0.05). Systolic anterior motion (SAM) of the mitral valve occurred in 2 patients with the Physio II ring and no patients with the PR. Up to 8 years follow-up, all patients in both groups were alive with NYHA functional class I-II symptoms and mild or less MR.

CONCLUSIONS

The PR is suitable for all patients with significant MR due to FMV/MVP who require MV repair. The precise fit of the PR to the mitral annulus better preserves valve area and sphincter function of the mitral annulus, prevents SAM and provides excellent short and long-term results.

摘要

背景

对于因二尖瓣脱垂(MVP)/瓣叶冗长所致的严重二尖瓣反流(MR)患者,应用瓣环成形环进行二尖瓣修复是首选术式。二尖瓣瓣环的大小、形状及活动度在患者之间可能存在显著差异,因此市售的瓣环成形环可能并不适合每一位患者。

方法

在手术室中,使用涤纶片和钛结扎夹轻松构建“个性化瓣环”(PR),以使其与每个二尖瓣瓣环的形状和大小定制适配。127例因MVP/瓣叶冗长所致严重MR的患者接受了二尖瓣修复手术;58例患者接受了PR,69例患者接受了市售的Carpentier-Edwards Physio II瓣环成形环。对患者记录进行回顾性分析。

结果

无手术死亡病例。两组患者的住院时间和输血量在统计学上无差异。PR组的二尖瓣瓣口面积(3.78±0.22)大于Physio II瓣环成形环组(3.13±0.21)(p<0.05)。PR组二尖瓣瓣环面积从收缩期到舒张期变化了14.35%±3.28%,而Physio II瓣环成形环组未发生变化(p<0.05)。使用Physio II瓣环成形环的2例患者出现二尖瓣收缩期前向运动(SAM),而使用PR的患者未出现。随访长达8年,两组所有患者均存活,纽约心脏协会(NYHA)心功能分级为I-II级,二尖瓣反流程度为轻度或更低。

结论

PR适用于所有因MVP/瓣叶冗长需要进行二尖瓣修复的严重MR患者。PR与二尖瓣瓣环的精确适配能更好地保留瓣口面积和二尖瓣瓣环的括约肌功能,预防SAM,并提供优异的短期和长期效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a057/6567592/06f57074bb6d/13019_2019_926_Fig1_HTML.jpg

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