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在二尖瓣修复治疗 II 型功能障碍时,是否应根据脱垂部位选择成形环假体?

Should annuloplasty prosthesis be selected dependent on the location of prolapse in mitral valve repair for type II dysfunction?

机构信息

Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.

Department of Cardiac Surgery, National Cerebral and Cardiovascular Center, Osaka, Japan.

出版信息

J Thorac Cardiovasc Surg. 2017 Dec;154(6):1915-1924.e6. doi: 10.1016/j.jtcvs.2017.06.049. Epub 2017 Jul 4.

Abstract

OBJECTIVE

This study explored the influence of prosthesis selection on long-term outcomes in patients who underwent mitral valve repair for mitral insufficiency (MI) due to type II dysfunction.

METHODS

We retrospectively reviewed 452 patients with MI who underwent mitral valve repair for type II dysfunction between 2001 and 2014. Of these, 167 patients (37%) presented with anterior leaflet prolapse (anterior group) and 285 (63%) presented with posterior prolapse (posterior group). Full rings were applied in 95 patients (57%) in the anterior group and in 54 patients (19%) in the posterior group, and partial bands were applied in all others. We compared long-term outcome and change of MI severity over time between patients with partial-band and full-ring repair in the anterior and in the posterior groups using a mixed-effect model with repeated measures and propensity score-matched analysis.

RESULTS

Ten-year survival of the cohort was 90.5%. Echocardiography revealed MI ≥ 3 at follow-up in 58 patients (12.8%). Twenty-one patients (4.6%) required reoperation; freedom from reoperation was 92.1% at 10 years. The MI severity over time in patients in the anterior group was higher than that in patients in the posterior group (P < .0001). Moreover, MI severity over time in patients with the partial band was higher than patients with the full ring in the anterior group (P = .0176). Propensity score-matched analysis in the anterior group, but not in the posterior group, revealed a significantly higher MI severity in patients with the partial band than those with the full ring over the study period (P = .04).

CONCLUSIONS

Full-ring annuloplasty is indicated in the setting of anterior prolapse to prevent recurrent MI, whereas prosthesis type is not a determinant of recurrent MI in the setting of posterior prolapse.

摘要

目的

本研究旨在探讨二尖瓣修复术治疗因 II 型病变导致的二尖瓣关闭不全(MI)患者中,人工瓣膜选择对长期预后的影响。

方法

我们回顾性分析了 2001 年至 2014 年间因 II 型病变接受二尖瓣修复术的 452 例 MI 患者。其中,167 例(37%)表现为前叶脱垂(前组),285 例(63%)表现为后叶脱垂(后组)。前组中 95 例(57%)采用全环,54 例(19%)采用部分环,其余均采用部分带。我们采用重复测量混合效应模型和倾向评分匹配分析比较了前组和后组中采用部分环和全环修复的患者之间的长期预后和 MI 严重程度随时间的变化。

结果

该队列的 10 年生存率为 90.5%。随访时,58 例患者(12.8%)超声心动图显示 MI≥3。21 例患者(4.6%)需要再次手术;10 年时无再手术率为 92.1%。前组患者的 MI 严重程度随时间的变化高于后组(P<0.0001)。此外,在前组中,与全环组相比,部分带组患者的 MI 严重程度随时间的变化更高(P=0.0176)。在前组中,倾向评分匹配分析显示,与全环组相比,部分带组患者在整个研究期间的 MI 严重程度更高(P=0.04),但在后组中未发现显著差异。

结论

在前叶脱垂的情况下,全环成形术是预防复发性 MI 的指征,而在后叶脱垂的情况下,人工瓣膜类型不是复发性 MI 的决定因素。

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