Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China.
Gene. 2014 Jan 1;533(1):21-5. doi: 10.1016/j.gene.2013.09.054. Epub 2013 Sep 25.
Interleukin-23 (IL-23) and IL-23 receptor (IL23R) play an important role during the T-helper 17 (Th17) cell-mediated inflammatory process as well as pathogenesis of multiple cancers. Several IL-23R single nucleotide polymorphisms (SNPs), especially rs6682925, rs10889677 and rs1884444 polymorphisms, are considered to have significant impacts on susceptibility of multiple cancers. A number of case-control studies have explored the role these genetic polymorphisms in development of carcinogenesis, but the conclusions are inconsistent. Therefore, we conducted this meta-analysis to systematically investigate the associations between the three genetic variants and multiple cancer risk.
A total of ten studies are eligible (12,211 patients and 14,650 controls). Pooled odds ratios (ORs) and the 95% confidence interval (95% CI) were appropriately calculated using either fixed-effect model or random-effect model.
Significant associations between rs6682925 or rs10889677 polymorphism and cancer risk were found (OR=1.11, 95% CI=1.03-1.21, P=0.007; or OR=0.85, 95% CI=0.71-0.92, P=0.001). However, there was no such association between rs1884444 genotypes and cancer susceptibility (P>0.05).
These findings reveal that the IL-23R rs6682925 and rs10889677 genetic variants play a more important part in pathogenesis of multiple cancers.
白细胞介素-23（IL-23）及其受体（IL23R）在辅助性 T 细胞 17（Th17）细胞介导的炎症过程以及多种癌症的发病机制中发挥着重要作用。几种 IL-23R 单核苷酸多态性（SNP），特别是 rs6682925、rs10889677 和 rs1884444 多态性，被认为对多种癌症的易感性有显著影响。许多病例对照研究探讨了这些遗传多态性在致癌作用中的作用，但结论并不一致。因此，我们进行了这项荟萃分析，以系统地研究这三种遗传变异与多种癌症风险之间的关系。
共有 10 项研究符合纳入标准（12211 名患者和 14650 名对照）。使用固定效应模型或随机效应模型适当计算合并的优势比（OR）和 95%置信区间（95%CI）。
rs6682925 或 rs10889677 多态性与癌症风险之间存在显著关联（OR=1.11，95%CI=1.03-1.21，P=0.007；或 OR=0.85，95%CI=0.71-0.92，P=0.001）。然而，rs1884444 基因型与癌症易感性之间没有这种关联（P>0.05）。
这些发现表明，IL-23R rs6682925 和 rs10889677 遗传变异在多种癌症的发病机制中起着更为重要的作用。
