采用电化学发光法测定口腔扁平苔藓患者血清皮质醇水平

Estimation of Serum Cortisol Levels in Oral Lichen Planus Patients with Electrochemiluminescence.

作者信息

Jose Sam, Mukundan Jayasree Vijayalakshmi, Johny Joseph, Tom Arun, Mohan Sunil Paramel, Sreenivasan Anjali

机构信息

Department of Oral Medicine and Radiology, PSM College of Dental Science and Research, Thrissur, India.

Department of Oral Medicine and Radiology, Sree Anjaneya Institute of Dental Sciences, Calicut, Kerala, India.

出版信息

J Pharm Bioallied Sci. 2019 May;11(Suppl 2):S265-S268. doi: 10.4103/JPBS.JPBS_7_19.

DOI:10.4103/JPBS.JPBS_7_19

PMID:31198350

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6555372/

Abstract

OBJECTIVES

The objectives of this study were to compare the serum cortisol level in oral lichen planus (OLP) patients with normal healthy individuals and to compare the serum cortisol level in patients with erosive and nonerosive forms of OLP.

MATERIALS AND METHODS

A case-control study involving 60 patients within the age group of 20-50 years was carried out. Group A included 15 subjects with nonerosive lichen planus, without skin involvement; Group B included 15 subjects with erosive lichen planus, without skin; and Group C included 30 subjects with no apparent lesions of the oral mucosa and the skin. From the cases and controls, 7mL venous blood was taken from median cubital vein two times (between 8 and 10 AM, and 4 and 6 PM) by using a 10 mL syringe from which 5 mL was taken for estimation of serum cortisol.

RESULTS

The serum cortisol levels of the erosive OLP patients were significantly higher than those of nonerosive OLP patients and controls. There was no significant difference in the serum cortisol levels between nonerosive OLP in comparison with controls.

摘要

目的

本研究的目的是比较口腔扁平苔藓（OLP）患者与正常健康个体的血清皮质醇水平，并比较糜烂型和非糜烂型OLP患者的血清皮质醇水平。

材料与方法

进行了一项病例对照研究，纳入60名年龄在20至50岁之间的患者。A组包括15名无皮肤受累的非糜烂性扁平苔藓患者；B组包括15名无皮肤受累的糜烂性扁平苔藓患者；C组包括30名口腔黏膜和皮肤无明显病变的受试者。从病例组和对照组中，使用10 mL注射器从肘正中静脉采集7 mL静脉血两次（上午8点至10点之间，下午4点至6点之间），其中5 mL用于血清皮质醇的测定。