Sushanthi L Casilda, Ramani Pratibha, Ramasubramanian Abilasha, Gheena S, Krishnan Reshma P
Department of Oral Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Indian J Dermatol. 2021 Nov-Dec;66(6):654-659. doi: 10.4103/ijd.ijd_95_21.
Lichen planus (LP) is an autoimmune, mucocutaneous, T-cell mediated chronic inflammatory disease that involves the oral mucosa. The prevalence of LP is 0.04-2% in general population with a female predilection. Patients with skin lesions also manifest oral lesions predominantly and about 25% present with only oral lesions. The aim of the systematic review is to analyze the serum cortisol levels in LP patients to elucidate the role of cortisol in pathogenesis of the lesion. A comprehensive search was done using electronic data bases such as PUBMED, EMBASE, SCIENCE DIRECT, COCHRANE, GOOGLE, manual search, and back references of the articles were extracted. A total of seven relevant articles were reviewed and analyzed. Electronic database and manual search identified 55 articles. Out of which, 33 were excluded after reading titles and removing duplication and 23 studies were evaluated in detail after reading the abstract and full text. A final of seven studies were included based on the inclusion criteria to meet the research question. All the studies analyzed the serum cortisol levels in LP patients and also in healthy subjects. Within the limitations of this review, it can be inferred that Cortisol is an established stress hormone and Serum cortisol estimation could be an important indicator in identifying susceptible oral lichen planus patients.
扁平苔藓（LP）是一种自身免疫性、皮肤黏膜性、T细胞介导的慢性炎症性疾病，累及口腔黏膜。LP在普通人群中的患病率为0.04%-2%，女性更为多见。有皮肤损害的患者也主要表现为口腔损害，约25%的患者仅出现口腔损害。本系统评价的目的是分析LP患者的血清皮质醇水平，以阐明皮质醇在该病发病机制中的作用。我们使用电子数据库如PUBMED、EMBASE、SCIENCE DIRECT、COCHRANE、GOOGLE进行了全面检索，并进行了手工检索，提取了文章的参考文献。共对7篇相关文章进行了综述和分析。电子数据库和手工检索共识别出55篇文章。其中，阅读标题并去除重复后排除33篇，阅读摘要和全文后对23项研究进行了详细评估。根据纳入标准，最终纳入7项研究以满足研究问题。所有研究均分析了LP患者以及健康受试者的血清皮质醇水平。在本综述的局限性范围内，可以推断皮质醇是一种公认的应激激素，血清皮质醇测定可能是识别易患口腔扁平苔藓患者的重要指标。
