Ghobadi Saeed, Rostami Zahra Hassanzadeh, Marzijarani Mohammad Salehi, Faghih Shiva
Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Prev Med. 2019 May 17;10:77. doi: 10.4103/ijpvm.IJPVM_242_17. eCollection 2019.
Recently, it has been found that Vitamin D can affect cardiometabolic risk factors. However, these findings have not been confirmed in younger population. We aimed to assess the associations of serum 25-hydroxyvitamin D (25(OH)D) and metabolic syndrome (MetS) components in Iranian children.
This cross-sectional study was conducted on 240 children aged 6-9 years old. Anthropometric indices (weight, height, waist circumference, and body fat), biochemical parameters (low-density lipoprotein, high-density lipoprotein, triglyceride [TG], fasting blood sugar, and serum 25(OH)D), systolic blood pressure (SBP) and diastolic blood pressure (DBP) blood pressure, and dietary intake and physical activity were measured. Multivariate linear regression analysis was used to assess the association of MetS components and serum 25(OH)D.
Mean age of children was 7.8 ± 1.06 year. Mean serum 25(OH)D concentration was 14.6 ± 10.64 ng/ml, and the prevalence of Vitamin D deficiency (serum 25(OH)D lower than 10 ng/ml) was 41.66%. Dietary intake of Vitamin D was 1.91 ± 1.8 mcg/day. Serum 25(OH)D was inversely associated with TG (β = -0.16; CI: -0.27, -0.04) after adjusting by age, gender, body mass index, physical activity, and some dietary components. Serum 25(OH)D was negatively associated with SBP (β = -0.02; CI: (-0.05, -0.004), and DBP (β = -0.02; CI: -0.05, -0.003); however, it was not significant anymore after adjustment for sodium, potassium, and fiber.
Vitamin D deficiency is alarming among Iranian children. Among the components of MetS, lower serum Vitamin D concentration was only associated with TG that could contribute in onset and progression of cardiometabolic disorders later in life.
最近，人们发现维生素D会影响心脏代谢风险因素。然而，这些发现在较年轻人群中尚未得到证实。我们旨在评估伊朗儿童血清25-羟基维生素D（25(OH)D）与代谢综合征（MetS）各组分之间的关联。
这项横断面研究针对240名6至9岁的儿童进行。测量了人体测量指标（体重、身高、腰围和体脂）、生化参数（低密度脂蛋白、高密度脂蛋白、甘油三酯[TG]、空腹血糖和血清25(OH)D）、收缩压（SBP）和舒张压（DBP），以及饮食摄入量和身体活动情况。采用多变量线性回归分析来评估MetS各组分与血清25(OH)D之间的关联。
儿童的平均年龄为7.8±1.06岁。血清25(OH)D的平均浓度为14.6±10.64 ng/ml，维生素D缺乏（血清25(OH)D低于10 ng/ml）的患病率为41.66%。维生素D的饮食摄入量为1.91±1.8 mcg/天。在对年龄、性别、体重指数、身体活动和一些饮食成分进行调整后，血清25(OH)D与TG呈负相关（β = -0.16；置信区间：-0.27，-0.04）。血清25(OH)D与SBP呈负相关（β = -0.02；置信区间：(-0.05, -0.004)），与DBP也呈负相关（β = -0.02；置信区间：-0.05，-0.003）；然而，在对钠、钾和纤维进行调整后，这种相关性不再显著。
伊朗儿童中维生素D缺乏情况令人担忧。在MetS的各组分中，较低的血清维生素D浓度仅与TG相关，这可能在日后导致心脏代谢紊乱的发生和发展。
