Mellati Ali Awsat, Sharifi Faranak, Faghihzade Soghrat, Mousaviviri Seyed Akbar, Chiti Hosain, Kazemi Seyed Ali Naghi
J Pediatr Endocrinol Metab. 2015 May;28(5-6):641-8. doi: 10.1515/jpem-2013-0495.
High prevalence of vitamin D insufficiency/deficiency has been reported in populations of different countries. The aim of this cross-sectional study was to determine the prevalence and association of vitamin D status with components of metabolic syndrome.
Lipid profile indices, anthropometric indices [body mass index and waist circumference (WC)], insulin resistance index (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), C-reactive protein, intact parathyroid hormone (iPTH), and serum 25-hydroxyvitamin D [25(OH)D] concentration were evaluated in 297 healthy schoolchildren aged 7-11 years. Multivariate linear regression was used to determine independent predictors associated with low serum 25(OH)D concentrations.
The mean serum 25(OH)D concentration was 14.12±8.20 ng/mL (35.3±20.5 nmol/L); 96% of children had low serum 25(OH)D levels, 31.0% were deficient, and 65.0% had insufficient levels of 25(OH)D. Vitamin D deficiency was higher in girls (χ²=13.66; p=0.00); 25(OH)D level was negatively associated with WC, HOMA-IR, SBP, DBP, and iPTH. In the multivariate model, WC, DBP, and HOMA-IR were significant independent predictor of low 25(OH)D concentrations.
The prevalence of low vitamin D level in the studied healthy children was high and it is correlated with some components of metabolic syndrome. Outdoor activity for optimum sun exposure and additional studies are needed to evaluate the underlying metabolic syndrome components and hypovitaminosis D complications.
不同国家人群中维生素D不足/缺乏的患病率较高。本横断面研究的目的是确定维生素D状态与代谢综合征各组分之间的患病率及关联。
对297名7 - 11岁健康学童的血脂谱指标、人体测量指标[体重指数和腰围（WC）]、胰岛素抵抗指数（HOMA - IR）、收缩压（SBP）、舒张压（DBP）、C反应蛋白、全段甲状旁腺激素（iPTH）以及血清25 - 羟维生素D [25(OH)D]浓度进行评估。采用多变量线性回归确定与低血清25(OH)D浓度相关的独立预测因素。
血清25(OH)D平均浓度为14.12±8.20 ng/mL（35.3±20.5 nmol/L）；96%的儿童血清25(OH)D水平较低，31.0%缺乏，65.0%的25(OH)D水平不足。女孩中维生素D缺乏情况更严重（χ² = 13.66；p = 0.00）；25(OH)D水平与WC、HOMA - IR、SBP、DBP和iPTH呈负相关。在多变量模型中，WC、DBP和HOMA - IR是低25(OH)D浓度的显著独立预测因素。
在所研究的健康儿童中，低维生素D水平的患病率较高，且与代谢综合征的某些组分相关。需要进行户外活动以获得最佳日照，还需要进一步研究来评估潜在的代谢综合征组分及维生素D缺乏症并发症。
