氧化应激与多囊卵巢综合征：简要综述
Oxidative Stress and Polycystic Ovary Syndrome: A Brief Review.
作者信息
Mohammadi Masoumeh
机构信息
Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Int J Prev Med. 2019 May 17;10:86. doi: 10.4103/ijpvm.IJPVM_576_17. eCollection 2019.
Abstract
Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders, occurring in 5-10% women in reproductive ages. Despite a long history of studies on PCOS, its etiology is still unknown. Oxidative stress is now recognized to play a central role in the pathophysiology of many different disorders, including PCOS. Although intracellular reactive oxygen species (ROS) production and propagation are controlled by highly complex antioxidant enzymatic and non-enzymatic systems, understanding of mechanisms that oxidative stress is important to develop strategies for prevention and therapy of PCOS. This article reviews the literature data related to the mechanisms of oxidative stress in PCOS.
摘要
多囊卵巢综合征（PCOS）是最常见的激素紊乱疾病之一，在育龄女性中的发病率为5%-10%。尽管对PCOS的研究历史悠久，但其病因仍不清楚。氧化应激现已被认为在包括PCOS在内的许多不同疾病的病理生理学中起核心作用。虽然细胞内活性氧（ROS）的产生和传播由高度复杂的抗氧化酶和非酶系统控制，但了解氧化应激机制对于制定PCOS的预防和治疗策略很重要。本文综述了与PCOS氧化应激机制相关的文献数据。
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