Liu K R, Peyman G A, Khoobehi B, Alkan H, Fiscella R
Department of Ophthalmology, University of Illinois College of Medicine at Chicago.
Ophthalmology. 1987 Sep;94(9):1155-9. doi: 10.1016/s0161-6420(87)33325-1.
Two groups of albino rabbits received an intravitreal injection of liposome-encapsulated trifluorothymidine. One group underwent a clearance study using high-performance liquid chromatography. The results of this study demonstrated a prolonged vitreal drug level within the range of ID50 for many strains of herpesvirus and human cytomegalovirus (CMV) at 28 days after injection. The eyes of another group were evaluated with preoperative and postoperative indirect ophthalmoscopy, electroretinography, and histologic examination. No retinal toxicity was found.
两组白化兔接受了玻璃体内注射脂质体包裹的三氟胸腺嘧啶。一组使用高效液相色谱法进行清除研究。该研究结果表明，注射后28天，许多疱疹病毒株和人巨细胞病毒（CMV）在半数感染剂量范围内玻璃体内药物水平延长。另一组兔子的眼睛通过术前和术后间接检眼镜检查、视网膜电图检查和组织学检查进行评估。未发现视网膜毒性。
