• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

核膜完整性丧失？没问题——BAF 来解决。

Loss of nuclear envelope integrity? No probLEM-BAF has it covered.

机构信息

Department of Cell Biology, Yale School of Medicine, New Haven, CT

Department of Molecular, Cell, and Developmental Biology, Yale University, New Haven, CT.

出版信息

J Cell Biol. 2019 Jul 1;218(7):2077-2079. doi: 10.1083/jcb.201905155. Epub 2019 Jun 14.

DOI:10.1083/jcb.201905155
PMID:31201264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6605804/
Abstract

Ruptures of the nuclear envelope can drive a catastrophic loss of nucleocytoplasmic compartmentalization. In this issue, Halfmann et al. (2019. https://doi.org/10.1083/jcb.201901116) describe a mechanism for surveilling the integrity of the nuclear barrier and coupling the sensing of nuclear ruptures to the recruitment of the nuclear envelope repair machinery.

摘要

核膜破裂会导致核质区室的灾难性丧失。在本期中，Halfmann 等人（2019 年，https://doi.org/10.1083/jcb.201901116）描述了一种监测核屏障完整性的机制，并将核破裂的感应与核膜修复机制的募集联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b731/6605804/68defad93477/JCB_201905155_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b731/6605804/68defad93477/JCB_201905155_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b731/6605804/68defad93477/JCB_201905155_Fig1.jpg

相似文献

1
Loss of nuclear envelope integrity? No probLEM-BAF has it covered.核膜完整性丧失？没问题——BAF 来解决。
J Cell Biol. 2019 Jul 1;218(7):2077-2079. doi: 10.1083/jcb.201905155. Epub 2019 Jun 14.
2
Nuclear envelope lipids request border surveillance.核膜脂质请求边界监测。
J Cell Biol. 2021 Mar 1;220(3). doi: 10.1083/jcb.202101164.
3
Repair of nuclear ruptures requires barrier-to-autointegration factor.核破裂的修复需要屏障至自动整合因子。
J Cell Biol. 2019 Jul 1;218(7):2136-2149. doi: 10.1083/jcb.201901116. Epub 2019 May 30.
4
Mechanisms by which barrier-to-autointegration factor regulates dynamics of nucleocytoplasmic leakage and membrane repair following nuclear envelope rupture.屏障自整合因子调节核膜破裂后核质泄漏和膜修复动态的机制。
bioRxiv. 2023 Dec 22:2023.12.21.572811. doi: 10.1101/2023.12.21.572811.
5
Seipin regulates the formation of nuclear lipid droplets from a distance.Seipin 远距离调控核脂质滴的形成。
J Cell Biol. 2021 Jan 4;220(1). doi: 10.1083/jcb.202011166.
6
Loss of Nuclear Envelope Integrity in Aging and Disease.衰老和疾病过程中核膜完整性的丧失。
Int Rev Cell Mol Biol. 2018;336:205-222. doi: 10.1016/bs.ircmb.2017.07.013. Epub 2017 Sep 18.
7
Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus.核膜破裂：肌动蛋白纤维正在挤压细胞核。
J Cell Biol. 2016 Oct 10;215(1):5-8. doi: 10.1083/jcb.201609102. Epub 2016 Oct 3.
8
Barrier-to-autointegration factor: a first responder for repair of nuclear ruptures.屏障整合因子：核破裂修复的急救员。
Cell Cycle. 2021 Apr;20(7):647-660. doi: 10.1080/15384101.2021.1892320. Epub 2021 Mar 8.
9
Mechanisms of A-Type Lamin Targeting to Nuclear Ruptures Are Disrupted in and Associated Progerias.核破裂中 A 型层粘连蛋白靶向机制在 和相关早老症中被破坏。
Cells. 2022 Mar 2;11(5):865. doi: 10.3390/cells11050865.
10
Challenging the "chromatin hypothesis" of cardiac laminopathies with mutant iPS cells.用突变诱导多能干细胞挑战心脏层粘连蛋白病的“染色质假说”。
J Cell Biol. 2019 Sep 2;218(9):2826-2828. doi: 10.1083/jcb.201907166. Epub 2019 Aug 19.

引用本文的文献

1
Mechanisms by which barrier-to-autointegration factor regulates dynamics of nucleocytoplasmic leakage and membrane repair following nuclear envelope rupture.屏障自整合因子调节核膜破裂后核质泄漏和膜修复动态的机制。
bioRxiv. 2023 Dec 22:2023.12.21.572811. doi: 10.1101/2023.12.21.572811.
2
OASIS/CREB3L1 is a factor that responds to nuclear envelope stress.OASIS/CREB3L1是一种对核膜应激作出反应的因子。
Cell Death Discov. 2021 Jun 29;7(1):152. doi: 10.1038/s41420-021-00540-x.
3
Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts.

本文引用的文献

1
An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system.一个 ESCRT-LEM 蛋白监控系统准备好直接监测核膜和核转运系统。
Elife. 2019 Apr 3;8:e45284. doi: 10.7554/eLife.45284.
LAP2β 的过表达可消除核层蛋白缺陷神经元和成纤维细胞中的核膜破裂。
Proc Natl Acad Sci U S A. 2021 Jun 22;118(25). doi: 10.1073/pnas.2107770118.
4
Barrier-to-autointegration factor: a first responder for repair of nuclear ruptures.屏障整合因子：核破裂修复的急救员。
Cell Cycle. 2021 Apr;20(7):647-660. doi: 10.1080/15384101.2021.1892320. Epub 2021 Mar 8.