Max Perutz Labs, University of Vienna and Medical University of Vienna, Vienna Biocenter Campus, Vienna, Austria.
J Cell Biol. 2021 Mar 1;220(3). doi: 10.1083/jcb.202101164.
In this issue, Thaller et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202004222) explore how the ESCRT protein Chm7 is recruited to sites of defective nuclear pore assembly. They show that a lipid, phosphatidic acid, is enriched at pathological nuclear envelope herniations, where it promotes Chm7 recruitment for membrane surveillance and repair.
在本期中，Thaller 等人（2021. J. Cell Biol. https://doi.org/10.1083/jcb.202004222）探讨了 ESCRT 蛋白 Chm7 如何被招募到有缺陷的核孔组装部位。他们发现一种脂质，即磷脂酸，在病理性核膜膨出部位富集，促进 Chm7 募集进行膜监测和修复。
